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945280
Antifungal Drugs
Description
Mind Map on Antifungal Drugs, created by lippoldm on 28/05/2014.
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usmle
Mind Map by
lippoldm
, updated more than 1 year ago
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Created by
lippoldm
about 10 years ago
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Resource summary
Antifungal Drugs
Membrane Function inhibitors
Amphotericin B
*serious, systemic mycoses Cryptococcus Blastomyces Coccidioides Histoplasma Candida Mucor
Can semi-bind to cholesterol in human membranes= Anemia; DOSE DEPENDENT NEPHROTOXICITY; Electrolyte imbalances; Fevers and chills
Nystatin (PO)
Oral Candidiasis
Binds ergosterol in cell membrane
'-Azoles'
Local and less serious systemic infections
Gynecomastia and liver dysfunction
Dec metabolism of some drugs due to action at cP450
Inhibit cytochrome p450
'-fungin'
Invasive aspergillosis Candida
Enzyme inhibition
Terbinafine
Dermatophytes (onychomycosis)
Abnormal LFT's
Antiprotozoan Therapies
Chloroquine
Toxoplasmosis
Retinopathy
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