9977992
Description
Mind Map by Jack Willach, updated more than 1 year ago
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Created by Jack Willach
over 6 years ago
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GPCRs
- Features
- Amplification
- G proteins
- Enzyme activation
- Enzyme activation
- Phosphorylation Cascades
- G proteins
- Specificity
Annotations:
- How selective a drug is for a receptor
- Clean Drug
Annotations:
- Only acts on one receptor
- Dirty drug
Annotations:
- Drug acts on many receptors
- Desensitisation
Annotations:
- Results in: 1) turning off the receptor 2) removing it from the surface
- Receptor turns off
Annotations:
- Normally by phosphorylating receptor
- Removing it from the surface
Annotations:
- Called internalisation Can be short or long term Long term causes increase or decrease in receptor expression
- Intergration
Annotations:
- Cell recieves multiple signals and turns it into a response, normally when there are opposing effects on 2nd messengers
- Net effect is the sum of the 2 receptor types (e.g. pars/sympathetic systems)
- Amplification
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