Flashcards
lecture 17
Flashcards do conjunto (25)
- 1in intoxication does the toxin have to presentit doesn't have to be present to cause disease symptoms
- 2where does cholera cause infectionthe small intestine
- 3what is the route of transmissionfecal to oral transmission
- 4what are the main symptomsvomiting and watery diarrhoea
- 5what is cholera and what family is it part ofit is an exotoxin it is part of the AB5 family
- 6where does it act and what do the B and A subunit doit acts intracellularly
the B subunit does binding and entry
the a subunit is for enzymatic activity - 7what is the mechanismthere is an increase in chloride secretion and this is through cAMP and PKA phosphorylation
- 8is there any physical damageno there is just a deregulation of cellular
- 9EHEC is transmitted bythe fecal oral route - through contaminated ground beef or pork
- 10what is EHEC caused bythe exotoxin shiga toxin
- 11describe the shiga toxinit is part of the AB5 family
- 12how is shiga toxin transportedfrom the cell surface to the cytosol via the golgi and ER (retrograde transport)
- 13what does the A subunit doit has enzymatic activity and modifies RNA
- 14what are some of the things that shiva toxin doesit stops protein translation
causes inflammation in the intestinal epithelium and apoptosis
loss of epithelial barrier function
bloody diarrhoea - 15what do cytocylins dothey cause direct cell damage by forming a pore through the membrane or enzymatically damaging the cell membrane with phospholipases
- 16what are hemolysinscytolysis that target red blood cells
- 17why do bacteria produce toxins that destroy host cellsspreading - destroyis tissues so that they can move deeper into the tissue
immune invasion - killing immune cells means that the bacteria escapes an immune response
nutrition - cells carry many nutrients such as iron that are useful to the bacteria - 18what is the name of the degradative enzymes that bacteria secreteexoenzymes
- 19what do exoenzymes dothey destroy protein and tissue allowing the bacteria to penetrate deeper tissue
- 20describe the infection of a burn woundthe pathogen is an opportunistic one and it attacks patients who already have a compromised immune function. the burn already compromises the skin barrier allowing access to the tissue underneath. in the underlying tissue there is a decrease in IgG, complement and neutrophils. the infection progresses by expansion from the initial site of infection at the burn. tissue necrosis due to bacterial toxins and exoenzymes occurs
- 21how does septicaemia occurbacteria that penetrate the tissue through the action of degradative enzymes enter the blood stream
- 22what is the most important enzymeselastases as they break down collagen, elastin and other host proteins such as complement, chemokines and IgG
- 23what are the names of some elastases and how do they actLas A and Las B and they act synergistically
Las A is a serine protease that nicks the protein
LasB is a zinc metalloprotease that fully degrades the nicked protein - 24what is C5a and what is it produced byit is a peptidase and is produced by streptococcus pyogenes
- 25what does C5a do and what does destruction of it causeit is a chemoattractant that causes neutrophil migration
destruction prevents neutrophil infiltration into infected sites
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- FlashCards sobre lecture 17, criado por nileesha Parbhu em 27-10-2014.
- Criado por
- nileesha Parbhu
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