Flashcards
Data interpretation/Drug Monitoring
Flashcards do conjunto (11)
- 1Clinical action limitLimit when GPs must start treatment
- 2+/- 1SD =? % population? For 2? For 3?+/- 1SD = 68%
+/- 2SD = 95%
+/- 3SD = 99% - 3Critical DifferenceHow much something has to change before it is considered a pathological shift.
- 4Formula for Critical Difference?CD= 2.8 x SQRT(SDa^2 +SDb^2)
- 5What is the assumption of the Therapeutic window?Assumes that the desired and undesired effects are related to the drug concn
- 6When is a drug w/ a narrow therapeutic window acceptable?If disease is life-threatening
- 7What do half-lives influence?- Dosing interval
- Implications of missed dose
-Implications of stopping drug - 8Clearance is influenced by?- Routes of metabolism
- Routes of excretion
- Distribution into other body compartments - 9Different tissues = diff profusion rates Example?Heart, kidney, lung
muscle, skin, adipose
bone, teeth - 10Dosing intervals of how many half lives until drug accumulation?<4
- 11Bioavailability formula?F= AUC extravascular/AUC IV
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- FlashCards sobre Data interpretation/Drug Monitoring, criado por suzukan em 17-12-2014.
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- suzukan
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