Phase I Liver Detoxification

Phase I Liver Detoxification

Cytochrome P450 enzymes

Primary Co-factors:

Vitamin C

Copper

Magnesium

Zinc

Glutathione

Secondary Co-factors:

Intermediate substrates

B1, B2, B3, B6, B9, B12

Iron

BCAA's

(Gly, Leu, Ile, Val)

Inhibitors

anti-histamines

benzodiazepines

naringinen

curcumin

capsaisin

nutrient deficiencies

Inducers

caffeine

nicotine

alcohol

saturated fats

pesticides

barbituates

Detoxifies:

codeine, warfarin, anti-histamines, steroids

ibuprofen, salicylates

caffeine, alcohol, vanillin, GI endotoxins

FAs, arachidonic acid

environmental toxins

Over-activity:

exceeding Phase II

overproduction of free radicals

Under-activity:

intolerances to perfume, caffeine, environmental chemicals