Intramembrous Ossification

Intramembrous Ossification

Mesenchymal stem cells aggregate and differentiate into osteoblasts

These form ossification centres

Peripheral osteoblasts continue to differentiate

Secretion of osteoid

Osteoid is secreted inwardly, trapping some osteobasts

These osteoblasts become osteocytes

Osteoid starts to calcify and harden

Continual deposition of osteoid leads to tabecular and compact bone

Mesenchymal stem cells differentiate into the periosteum

Internal trabecular bone becomes filled with red bone marrow