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74269
General /History of LTP/LTD
Descrição
Third Level/Tertiary Exams SYNAPTIC Mapa Mental sobre General /History of LTP/LTD, criado por ob8313 em 07-05-2013.
Sem etiquetas
synaptic
synaptic
third level/tertiary exams
Mapa Mental por
ob8313
, atualizado more than 1 year ago
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ob8313
aproximadamente 11 anos atrás
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General /History of LTP/LTD
Trisynaptic loop
medial and lateral PP-DG granule cells - MFP-CA3pyramidal-SCCP-CA1 pyramidal-Out
Associational commissural - CA3-CA3
on to CA3
Excitatory onto CA1 - MF, PP, AC
Interneurons - GABA
Extrinsic: ACH, 5HT, DA
Most commonly studied: CA3-CA1 - electrophysiological recordings
Synaptic Plasticity: change in functional coupling between discrete neuronal structures
Developmental - hrs - lifetime
Short-term - ms-mins
Long-term - hrs, months, years
Pathological: changed wiring
Epilepsy/neuropathic pain
Regenerative
Rewiring after trauma if connection broken
why?
Memory
Addiction/reward
Sensory - visual
Network maintenance
Network computation
Pathology
How?
Induction
Expression
Maintenance
Extinction
Pre-S
VG-function - membrane potential
Number of NT vesicles released
Content of each vesicle
No. of release sites
Post S
No. of receptors
Receptor efficiency
P(o)
Single channel conductance
Change in spine size/active zone No.
Ionic gradient - Cl-, K+
Trans-synaptic
Change in NT clearance
EC ion conc
EC pH
Stages of LTP
Early LTP - Protein Kinase dependent, protein synthesis and Transcription independent
Late LTP - Protein Kinase, Protein synthesis and Transcription dependent - transcription in soma - Ca2+ dependent 2nd messenger - CREB
STP: NMDAr dependent but not PK or PS dependent
Induction properties of LTP
Associativity
Induction is influenced by activity at other synapses
If weak pathway input immediatly preceeds strong pathway input then weak pathway (below cooperativity threshold) will be potentaited too
Co-operativity
Cooperativity between afferent fibres - intensity threshold for LTP
Need to stimulate enough fibres
Input-specificity- potentiation only occurs at active synpases
Homosynaptic
only conditioned synapse expreses plasticity
Heterosynaptic
Conditioned and some non-conditioned express plasticity
Goddard Lab - McNaughton et al 1978
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