AGING

AGING

1. DEFINITION

   • HALLMARKS OF AGING
     • telomerase overexpression and shelterin mutation
     • LOSS OF PROTEOSTASIS:
     • DEREGULATED NUTRIENT SENSING
     • MITOCHONDRIAL DYSFUNCTION
     • TELOMRERE ATTRITION
     • EPIGENETUIC ALTERATIONS
     • GENOMIC INSTABILITY
       • DAMAGE
         • NUCLEAR DNA
         • MT DNA
           • GENOMIC
     • CELLULAR SENESCENCE
     • STEM CELL EXHAUSTION
     • ALTERED INTRACELLULAR COMMUNICATION
   • THE PROGRESSIVE LOSS OF PHYSOLOGICAL INTEGRITY LEADING TO IMPIARED FUNCTION

2. THEORIES OF AGING

   • PROGRAMMED THEORIES
     • PROGRAMMED SENECENESE
     • ENDOCRINE
     • IMMOUNOLOGY
   • ERROR THEORY
     • WEAR AND TEAR
     • RATE OF LIVING
     • CROSS LINKING
     • FREE RADICALS
     • ERROR CATASTROPHE
   • GENETIC
   • MITOCHONDRIAL
   • CALORIE RESTRECTION
   • TELOMERE

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