PHARMACOLOGICAL ASPECTS OF HYPOTHALAMUS / PITUITARY & ADRENAL DISORDERS

PHARMACOLOGICAL ASPECTS OF HYPOTHALAMUS / PITUITARY & ADRENAL DISORDERS

1. physiology

2. Growth Hormone

   • somatropin,somatrem(synthetic analog)
   • To improve growth in children with GH deficiency
   • Adverse
     • Carpal tunnel syndrome, hyperglycemia
   • Somatostatin
     • Somatotropin releasing inhibiting hormone
     • Synthetic
       • 1 Octreotide 2 Pegvisomant
       • uses
         • Acromegaly. Carcinoid tumors. Pancreatic tumors
       • Adverse
         • sludge(gallstone)

3. ERGOT DERIVATIVES (DOPAMINE AGONIST (D2)

   • Decrease prolactin
   • Bromocriptine
   • USES
     • Hyperprolactinemia
     • Parkinsonism
   • effecs
     • syncope,postural hypotension, psychosis

4. Vassopressin

   • ADH
   • Uses
     • Neurogenic DI(pituitary)(central DI)
     • Nephrogenic DI(impaired renal response to AVP)
     • Constrict blood vessel
   • Adverse
     • coronary vasospasm
     • uterine contraction

5. Desmopressin

   • selective (V2) agonist
   • Uses
     • DI(Central,pituitary)(DOC) Bedwetting(children)

6. Adenocorticosteroids

   • MAGIC drug
     • Synthesis
     • uses
       • ALL Disease usable
         • Neurologic diseases
         • Pulmonary diseases
         • Renal disease
   • Immunosuppression
   • TOXICITY
     • Acute withdrawal
       • cerebral edema
       • fever, myalgia
     • Prolonged usage
       • fluid/lyte disturbances, hypertension, hyperglycemia, glycosuria
       • peptic ulcers, osteoporosis (direct inhibition of osteoblasts) myopathy, cataracts

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