Lipids and Dyslipidemia - created from Mind Map

Overview of Normal Lipid Metabolism Key players Role of cholesterol How Normal Lipid Metabolism Becomes Bad Atherosclerosis (attach PAD conference and see pathlogy) Treatment How does it happen Attached Study AidsQuiz - Peripheral Artery Disease

apo lipo

what is cholesterolforward cholesterol transportreverse cholesterol transport

Metabolic syndromeRisk FactorsRisk Markerswhat hyperlipidemia looks like

structure of normal arterial wall: -intima is closest to lumen and blood and has single layer of endothelial barrier cells -media is middle andn thickest -adventitia is outer normal endothelial layer: -mostly antithrombotic molecules -secrete vasodilators (NO/prostacyclin) and vasoconstrictors (endothelin). normally vasodilators predominate. -immune response -impermeable to large molecules -anti inflammatory -resist leukocyte adhesion normal smooth muscle cells -normal contractility -maintain ECM -mediainflammation endothelial cells -increased permeability -inflammatory cytokines -increased leukoocyte adhesion molecules -decreased vasodilation -decreased antithrombosis inflammation smooth muscle cells -increased inflammatory cytokines: IL 1 and TNF alpha -increased ECM synthesis -increased migration and proliferation into subintima

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Lipids and Dyslipidemia

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