Arsenate poisoning

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Arsenate (AsO4 3-), being a salt of arsenic, is an analog of inorganic phosphate

since arsenic like phosphorus is in Group V of the periodic table.

Arsenate can produce an unstable analog of 1,3-bisphosphoglycerate called 1-

arseno-3-phosphoglycerate, by replacing a phosphate group.

1-arseno-3-phosphoglycerate can be rapidly hydrolyzed in water to produce 3-phosphoglycerate and inorganic arsenate is regenerated.

The ATP-producing reaction of glycolysis (step 7) involving 1,3-

bisphosphoglycerate is thereby bypassed, resulting in no net formation of ATP from glycolysis.