AntiFungal, Antiviral and Antimycobacerial Drugs- Pharmacology- 4th Year- PMU

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AntiFungal, Antiviral and Antimycobacerial Drugs- Pharmacology- 4th Year- PMU
Med Student
Quiz por Med Student , atualizado more than 1 year ago
Med Student
Criado por Med Student mais de 5 anos atrás
213
3

Resumo de Recurso

Questão 1

Questão
Antifungals are:
Responda
  • tetracyclines
  • imidazoles
  • echinocandims
  • triazols

Questão 2

Questão
Synthetic antifungal drugs are
Responda
  • Nystatin
  • Itraconazole
  • Ketoconazole
  • Fluconazole

Questão 3

Questão
Antifungal antibiotics are:
Responda
  • Nystatin
  • Tetracycline
  • Gentamycin
  • Amphotericin B

Questão 4

Questão
Azoles:
Responda
  • are fungistatic
  • inhibit cell wall synthesis
  • inhibit ergosterol synthesis
  • inhibit hepatic CYP450 enzymes

Questão 5

Questão
lmidazoles are:
Responda
  • Fluconazole and ltraconazole
  • Miconazole and Econazole
  • Given topically
  • Given systematically

Questão 6

Questão
Ketoconazole is:
Responda
  • the only imidazole that can be given orally
  • used for treatment of bacterial skin infections
  • used topically for cutaneous fungal infections
  • used intravenously for treatment of systemic fungal infections

Questão 7

Questão
Fluconazole:
Responda
  • it is non- steroidal anti-inflammatory drug
  • is triazole antifungal drug
  • is administered orally or intravenously
  • is excreted mainly unchanged with the urine

Questão 8

Questão
ADRs of azole antifungals are:
Responda
  • hepatotoxicity
  • endocrine disorders
  • nephrotoxicity
  • nausea, vomiting

Questão 9

Questão
Point the correct statements for Nystatin:
Responda
  • has fungistatic activity
  • causes gastrointestinal disturbances
  • is effective against Trichomonas vaginalis
  • is effective against Candida species

Questão 10

Questão
ADRs of Amphoteracin B are:
Responda
  • renal impairment
  • hypokalemia
  • hypotension
  • liver impairment

Questão 11

Questão
Antiviral drugs act by following mechanisms
Responda
  • inhibition of viral “uncoating”
  • inhibition of viral DNA or RNA synthesis
  • inhibition of viral proteases
  • inhibition of viral penetration into the cell

Questão 12

Questão
Point out the correct statements for Aciclovir:
Responda
  • it inhibits viral DNA polymerase
  • it is used for “treatment of herpesvirus infections
  • it inhibits neuraminidase enzyme
  • can be applied topically, orally or intravenously

Questão 13

Questão
ADRs of Aciclovir are:
Responda
  • hepatotoxicity
  • renal impairment
  • local irritation
  • encephalopathy (at high i.v. doses)

Questão 14

Questão
Drugs for prevention and treatment of flu are:
Responda
  • Aciclovir (Zovirax)
  • Amantadin (Symmetrel)
  • Rimantadin (Flumadine)
  • Oseltamivir (Tamiflu)

Questão 15

Questão
Mechanism of action of Oseltamivir (Tamiflu) is
Responda
  • interference with the function of the viral M2 protein
  • inhibition of specific neuraminidase enzyme
  • inhibition of reverse transcriptases
  • inhibition of proteases

Questão 16

Questão
For Amantadine and Rimantadine is true:
Responda
  • resistance can develop rapidly
  • they are effective against both type A and type B influenza
  • they are effective against type A influenza viruses
  • they interfere with the function of the viral M2 protein and block uncoating of the Virus particles

Questão 17

Questão
Mechanisms of action of drugs for treatment of HIV infection are:
Responda
  • inhibition of reverse transcriptase
  • inhibition of HIV protease
  • inhibition of HIV entry into the host cell
  • inhibition of the insertion of proviral DNA. into the host cell genome

Questão 18

Questão
Point out the correct statements for Zidovudin;
Responda
  • it blocks HIV reverse transcriptase
  • it blocks HIV protease
  • it is a nucleoside analogue
  • it can cause anemia and neutropenia

Questão 19

Questão
ADRS of Nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) are:
Responda
  • peripheral neuropathy
  • pancreatitis
  • polymyositis
  • glaucoma

Questão 20

Questão
HIV protease inhibitors are:
Responda
  • Zidovudin
  • Indinavir
  • Ritonavir
  • Aciclovir

Questão 21

Questão
For HIV protease inhibitors is true:
Responda
  • protease inhibition prevents maturation of the viral particles
  • they are enzyme inducers
  • they are enzyme inhibitors
  • they are combined with other antiretroviral drugs in the treatment of HIV infection

Questão 22

Questão
ADRs of HIV protease inhibitors are:
Responda
  • hyperlipidaemia
  • insulin resistance and hyperglycaemia
  • hypoglycaemia
  • fat redistribution

Questão 23

Questão
Inhibitor of both hepatitis B virus (HBV) and HIV reverse transcriptases is:
Responda
  • Zidovudin
  • Lamivudin
  • Aciclovir
  • lndinavir

Questão 24

Questão
Protease inhibitor for treatment of chronic hepatitis C infection is:
Responda
  • Aciclovir
  • Telaprevir
  • Zidovudin
  • Oseltamivir

Questão 25

Questão
Antimycobacterial drugs are:
Responda
  • Rifampicin
  • Isoniazid
  • Ethambutol
  • Amoxicillin

Questão 26

Questão
Rifampicin (Rifampin):
Responda
  • is bactericidal antibiotic with antimycobacterial activity
  • is antiviral drug
  • is broad spectrum antibiotic
  • is enzyme inducer

Questão 27

Questão
Mechanism of action of Rifampicin (Rifampin) is
Responda
  • inhibition of cell wall synthesis
  • inhibition of 50 S ribosomal subunit
  • inhibition of DNA-dependent RNA polymerase
  • increased cell membrane permeability

Questão 28

Questão
ADRs of Rifampicin (Rifampin) are:
Responda
  • heart failure
  • orange-red color of urine and other secretions
  • hepatotoxicity
  • hypoglycaemia

Questão 29

Questão
Point out the correct statements for lsoniazid:
Responda
  • inhibits the synthesis of essential for mycobacteria mycolic acid
  • it is metabolized by, acetylation
  • it is specific for treatment of M. Tuberculosis
  • it is active against broad spectrum of bacteria

Questão 30

Questão
ADRs of lsoniazld are:
Responda
  • renal impairment
  • peripheral neuropathy
  • convulsions
  • hepatitis

Questão 31

Questão
lsoniazid-induced peripheral neuropathy can be avoided by:
Responda
  • supplementation with vitamin B1
  • supplementation with vitamin A
  • supplementation with vitamin B6
  • supplementation with vitamin B12

Questão 32

Questão
ADRs of Pyrazinamide are:
Responda
  • hepatotoxicity
  • arrhythmia
  • hyperuricaemia
  • hypoglycaemia

Questão 33

Questão
Ethambutol:
Responda
  • is bacteriostatic antimycobacterial drug
  • may cause liver failure
  • may cause optic neuritis
  • inhibits synthesis of the mycobacterial cell wall

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