Quiz
AntiFungal, Antiviral and Antimycobacerial Drugs- Pharmacology- 4th Year- PMU
Perguntas do quiz (33)
1Antifungals are:
- Atetracyclines
- Bimidazoles
- Cechinocandims
- Dtriazols
2Synthetic antifungal drugs are
- ANystatin
- BItraconazole
- CKetoconazole
- DFluconazole
3Antifungal antibiotics are:
- ANystatin
- BTetracycline
- CGentamycin
- DAmphotericin B
4Azoles:
- Aare fungistatic
- Binhibit cell wall synthesis
- Cinhibit ergosterol synthesis
- Dinhibit hepatic CYP450 enzymes
5lmidazoles are:
- AFluconazole and ltraconazole
- BMiconazole and Econazole
- CGiven topically
- DGiven systematically
6Ketoconazole is:
- Athe only imidazole that can be given orally
- Bused for treatment of bacterial skin infections
- Cused topically for cutaneous fungal infections
- Dused intravenously for treatment of systemic fungal infections
7Fluconazole:
- Ait is non- steroidal anti-inflammatory drug
- Bis triazole antifungal drug
- Cis administered orally or intravenously
- Dis excreted mainly unchanged with the urine
8ADRs of azole antifungals are:
- Ahepatotoxicity
- Bendocrine disorders
- Cnephrotoxicity
- Dnausea, vomiting
9Point the correct statements for Nystatin:
- Ahas fungistatic activity
- Bcauses gastrointestinal disturbances
- Cis effective against Trichomonas vaginalis
- Dis effective against Candida species
10ADRs of Amphoteracin B are:
- Arenal impairment
- Bhypokalemia
- Chypotension
- Dliver impairment
11Antiviral drugs act by following mechanisms
- Ainhibition of viral “uncoating”
- Binhibition of viral DNA or RNA synthesis
- Cinhibition of viral proteases
- Dinhibition of viral penetration into the cell
12Point out the correct statements for Aciclovir:
- Ait inhibits viral DNA polymerase
- Bit is used for “treatment of herpesvirus infections
- Cit inhibits neuraminidase enzyme
- Dcan be applied topically, orally or intravenously
13ADRs of Aciclovir are:
- Ahepatotoxicity
- Brenal impairment
- Clocal irritation
- Dencephalopathy (at high i.v. doses)
14Drugs for prevention and treatment of flu are:
- AAciclovir (Zovirax)
- BAmantadin (Symmetrel)
- CRimantadin (Flumadine)
- DOseltamivir (Tamiflu)
15Mechanism of action of Oseltamivir (Tamiflu) is
- Ainterference with the function of the viral M2 protein
- Binhibition of specific neuraminidase enzyme
- Cinhibition of reverse transcriptases
- Dinhibition of proteases
16For Amantadine and Rimantadine is true:
- Aresistance can develop rapidly
- Bthey are effective against both type A and type B influenza
- Cthey are effective against type A influenza viruses
- Dthey interfere with the function of the viral M2 protein and block uncoating of the Virus particles
17Mechanisms of action of drugs for treatment of HIV infection are:
- Ainhibition of reverse transcriptase
- Binhibition of HIV protease
- Cinhibition of HIV entry into the host cell
- Dinhibition of the insertion of proviral DNA. into the host cell genome
18Point out the correct statements for Zidovudin;
- Ait blocks HIV reverse transcriptase
- Bit blocks HIV protease
- Cit is a nucleoside analogue
- Dit can cause anemia and neutropenia
19ADRS of Nucleoside and nucleotide reverse transcriptase inhibitors (NRTIs) are:
- Aperipheral neuropathy
- Bpancreatitis
- Cpolymyositis
- Dglaucoma
20HIV protease inhibitors are:
- AZidovudin
- BIndinavir
- CRitonavir
- DAciclovir
21For HIV protease inhibitors is true:
- Aprotease inhibition prevents maturation of the viral particles
- Bthey are enzyme inducers
- Cthey are enzyme inhibitors
- Dthey are combined with other antiretroviral drugs in the treatment of HIV infection
22ADRs of HIV protease inhibitors are:
- Ahyperlipidaemia
- Binsulin resistance and hyperglycaemia
- Chypoglycaemia
- Dfat redistribution
23Inhibitor of both hepatitis B virus (HBV) and HIV reverse transcriptases is:
- AZidovudin
- BLamivudin
- CAciclovir
- Dlndinavir
24Protease inhibitor for treatment of chronic hepatitis C infection is:
- AAciclovir
- BTelaprevir
- CZidovudin
- DOseltamivir
25Antimycobacterial drugs are:
- ARifampicin
- BIsoniazid
- CEthambutol
- DAmoxicillin
26Rifampicin (Rifampin):
- Ais bactericidal antibiotic with antimycobacterial activity
- Bis antiviral drug
- Cis broad spectrum antibiotic
- Dis enzyme inducer
27Mechanism of action of Rifampicin (Rifampin) is
- Ainhibition of cell wall synthesis
- Binhibition of 50 S ribosomal subunit
- Cinhibition of DNA-dependent RNA polymerase
- Dincreased cell membrane permeability
28ADRs of Rifampicin (Rifampin) are:
- Aheart failure
- Borange-red color of urine and other secretions
- Chepatotoxicity
- Dhypoglycaemia
29Point out the correct statements for lsoniazid:
- Ainhibits the synthesis of essential for mycobacteria mycolic acid
- Bit is metabolized by, acetylation
- Cit is specific for treatment of M. Tuberculosis
- Dit is active against broad spectrum of bacteria
30ADRs of lsoniazld are:
- Arenal impairment
- Bperipheral neuropathy
- Cconvulsions
- Dhepatitis
31lsoniazid-induced peripheral neuropathy can be avoided by:
- Asupplementation with vitamin B1
- Bsupplementation with vitamin A
- Csupplementation with vitamin B6
- Dsupplementation with vitamin B12
32ADRs of Pyrazinamide are:
- Ahepatotoxicity
- Barrhythmia
- Chyperuricaemia
- Dhypoglycaemia
33Ethambutol:
- Ais bacteriostatic antimycobacterial drug
- Bmay cause liver failure
- Cmay cause optic neuritis
- Dinhibits synthesis of the mycobacterial cell wall
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- AntiFungal, Antiviral and Antimycobacerial Drugs- Pharmacology- 4th Year- PMU
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