409269
Descrição
Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312
mais de 10 anos atrás
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Questão 1
Questão
Give an example of a Class 1 Onocgene- Growth Factors
Responda
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Erb-B
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ERK
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Sis
Questão 2
Questão
What is the function of the sis protein?
Responda
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Forms a PDGF(Beta) chain
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Forms a IPGF(Beta) chain
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Forms a IGF1(Beta) chain
Questão 3
Questão
Name the two ways a cell can access extra Growth factor
Responda
-
A virus produces extra growth factor as it replicates
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A cell begins to make it's own growth factor through growth factor genes
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A cell begins to steal growth factor from surrounding cells
Questão 4
Questão
Name the Class 2 oncogene
Responda
-
Growth Factor Receptors
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Growth Factors
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Intracellular Transducers
Questão 5
Questão
Name a Class 2 Oncogene
Responda
-
Erb-B
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Sis
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IGF1
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TGFB
Questão 6
Questão
How does Erb-b become oncogene?
Responda
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....bind permanently to their ligand and so become constitutionally active
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... no longer need their ligand to activate become constitutionally active
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...form a constitutionally active dimer
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...no longer needs to dimerise to activate
Questão 7
Questão
What is erb-b?
Responda
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Family of tyrosine kinase receptors that bind to EGF
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Family of tyrosine kinase receptors that bind to TGFB
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Family of tyrosine kinase receptors that bind to IGF1
Questão 8
Questão
Similarly, in 'neu' receptors, what replaces the Valine to make a constantly active receptor?
Responda
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Glutamine
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Glutamic Acid
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Glutamate
Questão 9
Questão
What is Herceptin?
Responda
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A tyrosine kinase agonist?
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A humanised monoclonal antibody
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An Erb-B agonist
Questão 10
Questão
What does Herceptin bind to?
Responda
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Erb B
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HER2
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Tyrosine Kinase
Questão 11
Questão
Name the 3rd Class of Oncogenes
Responda
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Growth factors
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Transcription factors
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Intracellular transducers
Questão 12
Questão
Which of the following is a class 3A oncogoene?
Responda
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Erb-B
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Src
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c-myc
Questão 13
Questão
What determines the types of src tyrosine kinase present in the cell?
Responda
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The cell type
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The stage of the cell cycle
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The age of the cycle
Questão 14
Questão
What is the role of Cellular Transducers
Responda
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Relay information to the nucleus to regulate gene transcription
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Relay information to the ribosomes to regulate protein synthesis
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Relay information to the Golgi Complex to regulate cell receptor production
Questão 15
Questão
What allows Src to stick to the cytoplasm
Responda
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A modified lipid
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A modified glycoprotein
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A modified phospholipid
Questão 16
Questão
Name the substance that anchors src to the membrane
Responda
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Myristate
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Palmatite
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Acetylate
Questão 17
Questão
What holds src kinase shut in its inactive form?
Responda
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A phosphate on Tyr 527 in its inactive form & the SH2 domain
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A phosphate on Tyr 527 in its inactive form & the SH3 domain
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A phosphate on Tyr 537 in its inactive form & the SH2 domain
Questão 18
Questão
Put the following domains of Src in order
A- Unique Domain
B- Sh2 Domain
C-Catalytic Domain
D- Regulatory Domain
E- SH3
Responda
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A-B-E-C-D
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A-B-C-D-E
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A-B-D-E-C
Questão 19
Questão
What is the focus of an SH3 domain?
Responda
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Protein- protein interaction
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Protein- phosphotyrosine interaction
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Protein-phosphoserine interactoin
Questão 20
Questão
What sequence is favored by SH3 domains?
Responda
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Proline rich; Pro-X-X-Pro
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Histadine rich; His-X-X-His
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Gycine rich; Gy-X-X-Gly
Questão 21
Questão
What is required for Src to activate?
Responda
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For the protein to be at the membrane
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For the protein to be cytosolic
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The SH2 domain then releases the regulatory domain and binds to P-Tyrosine Kinase
Questão 22
Questão
What happens to the regulatory domain once the SH2 domain has released it?
Responda
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It's dephosphorylated by a phosphatase at the membrane at Tyr 527
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It's phosphorylated by the tyrosine kinase at Tyr 527
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Nothing
Questão 23
Questão
What tyrosine residue is phosphorylated by tyrosine kinase?
Responda
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416 on the activation lip
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417 on the activation lip
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418 on the activation lip
Questão 24
Questão
What is the most common oncogene form of src?
Responda
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Loss of regulatory domain (last 19 amino acids) so it cannot be phosphorylated
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Loss of SH2 domain so it cannot bind to regulatory domain when phosphorylated
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Modified lipid binds permanently to the membrane
Questão 25
Questão
Ras is the name of a small family of what?
Responda
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GTPase's
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ATPase's
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UTPase's
Questão 26
Questão
What process localyses Ras to the membrane?
Responda
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Acetylation
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Methylation
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Farnesylation
Questão 27
Questão
What is sos?
Responda
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A GAP
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A GEF
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A GDI
Questão 28
Questão
Where does GTP bind to ras?
Responda
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At the C and N terminus
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In the centre
Questão 29
Questão
What is the purpose of the discrete domain of Ras
Responda
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To bind GTP
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To bind GDP
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To bind downstream molecules
Questão 30
Questão
What are GDI's?
Responda
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Guanine Nucleotide Disassociation Inhibitors
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Guanine Nucleotide Dimerisation Inhibitors
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Gunanine Nucleotide Decamerisation Inhibitors
Questão 31
Questão
What is the purpose of a GDI and how it controlled?
Responda
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By molecules recruited to the tyrosine receptor
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Bind to Ras and prevent activation
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Bind to Ras and prevent de-activation
Questão 32
Questão
In which domains can a single mutation turn Ras into an oncogene?
Responda
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L1
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L2
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L3
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L4
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L5
Questão 33
Questão
What is the role of GRB2
Responda
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Binds Ras to membrane
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Binds Ras to TK receptor
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Binds Ras to Raf
Questão 34
Questão
How many SH2 domains does GRB2 have?
Responda
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2- both in the middle
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2- one on each end
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1 in the middle
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1 at the N terminus
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1 at the C terminus
Questão 35
Questão
What protein is used by Src to activate Ras?
Responda
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Srk
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Sch
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Shc
Questão 36
Questão
How does src phosphorylate the protein that activates Ras?
Responda
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Binds to SH3 domain
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Binds to SH2 domain
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Binds to discrete domain
Questão 37
Questão
Name the two proteins for which phosphorylated Shc has a very high affinity?
Responda
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Ras
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Sos
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GRB2
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GDI
Questão 38
Questão
Name the 4th class of oncogenes
Responda
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Growth factors
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Cellular Transporters
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Growth Factor Receptors
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Transcription factors
Questão 39
Questão
Name a class 4 oncogene
Responda
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Src
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Ras
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Jun
Questão 40
Questão
Name the part of c-jun that causes dimerisation
Responda
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Leu Zipper
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His zipper
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Ala zipper
Questão 41
Questão
Where is the unique sequence of c-jun and what is it's role?
Responda
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Near the center
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Near the c-terminus
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Near the n-terminus
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Defines family member
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Determines where in the DNA c-jun binds
Questão 42
Questão
Put the domains of C-jun in the correct order A-Leu Zipper B- Delta Domain C-Transcription Domain D- Unique Domain E- DNA Binding Domain
Responda
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D-B-C-E-A
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D-E-A-B-C
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C-A-D-B-E
Questão 43
Questão
How does C-jun function
Responda
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As a homodimer
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As a heterodimer
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As both
Questão 44
Questão
What is the first step of c-jun homodimer activation?
Responda
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Dephosphorylation by PKC
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Phosphorylation by JNK (ERK parallel protein)
Questão 45
Questão
What is the second step of c-jun homodimer activation?
Responda
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Dephosphorylation by PKB
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Phosphorylation by JNK
Questão 46
Questão
What part(s) of c-jun is lost to make it an oncogene?
Responda
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Unique sequence
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Delta Domain
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Leu zipper
Questão 47
Questão
Name a protein likely to form a heterodimer with c-jun
Responda
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AFK
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AFT
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AFR
Questão 48
Questão
What tends to be transcribed by the first c-jun heterodimer to form?
Responda
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c-jun
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AFK
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Fos
Questão 49
Questão
What is the second protein to heterodimerise with c-jun?
Responda
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Fos
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Fas
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Fis
Questão 50
Questão
What is the name of the second heterodimer formed by c-jun?
Responda
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AP1
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Ap2
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AP
Questão 51
Questão
What is required for Fos transcription?
Responda
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TCF/AFK to be activated by ERK
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AFK to be activated by ERK
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TCF to be activated by ERK
Questão 52
Questão
What sequences does AP1 bind to?
Responda
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TGAC
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GTAC
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GGAC
Questão 53
Questão
What is transcribed by AP1?
Responda
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Transcription factors
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Ribosomal proteins
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Growth factors
Questão 54
Questão
Is Cyclin D1 transcribed by Jun?
Responda
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Yes
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No
Questão 55
Questão
What happens if the signal activating AP1 persists for 30 mins?
Responda
-
It's activity is increased further by phosphorylation
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It's activity is increased further by methylation
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By Jnk/Erk
Questão 56
Questão
What transcribes C-Myc?
Responda
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API
-
Fos
-
c-Jun
Questão 57
Questão
How long is the half life of C-myc?
Responda
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5-10 mins
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5-10 seconds
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3-5 mins
Questão 58
Questão
What does Myc bind to in order to interact with E-Box sequences?
Responda
-
Max
-
Mad
-
Mac
Questão 59
Questão
Why is Ubiquitin ligase transcribed by c-myc?
Responda
-
Halts protein turnover & allows protein levels to build up
-
Increases protein turnover so only new proteins are involved in the cell cycle
Questão 60
Questão
In normal cells, which of the following is in excess, and why?
Responda
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Max, so the dimer only forms when Myc levels are signaled to rise
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Mic, so the dimer only forms when Max levels are signalled to rise
Questão 61
Questão
How are Max homodimers inhibitory?
Responda
-
They block jun transcription sites
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They block jun expression promoters
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They block myc expression promoters
Questão 62
Questão
What is different in tumor cells from normal cells (concerning myc/max levels)?
Responda
-
Myc levels are always higher than Max
-
Max levels are always higher than myc
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