450600
Descrição
Quiz por gina_evans0312, atualizado more than 1 year ago
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Criado por gina_evans0312
mais de 10 anos atrás
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Questão 1
Questão
What is the main role of a molecular chaperone?
Responda
-
Assist in the folding of other proteins
-
Assist in the unfolding of other proteins
-
Assist in the assembly of other proteins
-
Assist in the disassembly of other proteins
Questão 2
Questão
Chaperone proteins are permanent parts of the proteins they fold
Responda
- True
- False
Questão 3
Questão
Why are chaperone proteins necessary?
Responda
-
Some proteins have complex folding pathways,
-
Some proteins are inherently soluble
-
Useful for multimeric assembly
-
So many proteins folding and interacting mean some need help
Questão 4
Questão
Name the role of the domain highlighted in bacterial trigger factor
Responda
-
PPIase domain
-
Interacts with polypeptide as it comes off the ribosome
-
Binds to L23 of the ribosome
Questão 5
Questão
The highlighted domain of Bacterial trigger factor binds to L23 of the ribosome
Responda
- True
- False
Questão 6
Questão
The bacterial ribosome and bacterial trigger factor form a complex, so the protein is folded as it comes off the ribosome
Responda
- True
- False
Questão 7
Questão
The N-domain of the bacterial trigger factor bind to what subunit of what size ribosome?
Responda
-
L23
-
L24
-
L25
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50s
-
40s
-
30s
Questão 8
Questão
After the protein interacts with the T.F, it may interact with what proteins?
Responda
-
DNAK
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DNAJ
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DNAL
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Gro-EL
-
Gro-ER
Questão 9
Questão
What percent of proteins can fold unaided after interacting with DNAK/J?
Responda
-
70%
-
65%
-
75%
Questão 10
Questão
10-15% of proteins need to use the lidded protein chaperone syastem
Responda
- True
- False
Questão 11
Questão
15-18% of proteins need further _ interactions?
Responda
-
DNAK
-
DNAJ
-
Gro-El
Questão 12
Questão
Yeast has no trigger factor
Responda
- True
- False
Questão 13
Questão
In yeast, what protein folding complex interacts with the proteins first?
Responda
-
Nascent Polypeptide Associated Complex (NAC)
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The Ribosome Associated Complex (RAC)
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CCT
Questão 14
Questão
The RAC complex is made of which proteins?
Responda
-
Zuptin
-
Hsp40
-
SSZ
-
Hsp70
Questão 15
Questão
SSB is separated from the RAC but also chaperones protein folding
Responda
- True
- False
Questão 16
Questão
The NAC is made of A and B homologues
Responda
- True
- False
Questão 17
Questão
What is the role of the NAC?
Responda
-
Bind to nascent proteins and prevent aggregation
-
Binds to nascent proteins and degrades them based on protein concentrations in the cell
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Binds to nascent proteins and folds them
Questão 18
Questão
Human cellss don't possess an NAC
Responda
- True
- False
Questão 19
Questão
Humans have an hRAC rather than an RAC
Responda
- True
- False
Questão 20
Questão
The human version of the RAC contains which two proteins?
Responda
-
MPP11
-
SSz
-
Hsp70L1
-
SSb
Questão 21
Questão
Name the lidded protein chaperone found in yeast and humans
Responda
-
Gro-El
-
CCT
-
SSb
-
Hsp70L1
Questão 22
Responda
-
Hsp40/70- humans
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Hsp40/70- yeast
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SSa/YDJ1- yeast
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Ssa/Ydj1- humans
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Prefoldin
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