Questão 1
Questão
L’acide phosphorique est tri-basique, avec des valeurs de pKa de 2.14, 6.88 et 12.4. Quelle forme ionique est prédominante à pH = 5.9 ?
Responda
-
H3PO4
-
H2PO4-
-
HPO42-
-
PO43-
Questão 2
Questão
What is the basic formula of Carbohydrates?
Responda
-
Cn(OH)n
-
Cn(CO2)n
-
Cn(H2O)n
-
C(H2O)n
Questão 3
Questão
Which of these is not these is not a polysaccharide?
Responda
-
Cellulose
-
Glycogen
-
Starch
-
Fructose
Questão 4
Questão
Long chains of single sugars covalently linked describes what types of carbohydrates?
Responda
-
Oligosaccharides
-
Multisaccharides
-
Polysaccharides
-
Megasaccharides
Questão 5
Questão
Which pair of molecules are epimers?
Questão 6
Questão
Which of these structures is glucose?
Questão 7
Questão
Galactose is a ___ epimer of glucose.
Questão 8
Questão
Which one of these is a ketohexose
Responda
-
Fructose
-
Glucose
-
Ribose
-
2-Deoxy-Ribose
Questão 9
Questão
Which of these is not true?
Responda
-
Enantiomers are stereoisomers that are not mirror images
-
In sugars that contain the most chiral centers only the one that is the most distant from the caronyl carbon is designated as D or L
-
hemiacetals are formed by alcohols attacking aldehydes
-
Alcohol oxygen atom is nucleophilic
Questão 10
Questão
During the cyclisation of Monosaccharides which is/are true?
Responda
-
The carbon atom furthest from the former carbonyl atom becomes the anomeric carbon
-
The position of anomeric carbon's oxygen determines whether the anomer is α or β
-
The position of the anomeric carbon's hydroxyl group determines whether the anomer is α or β
-
The carbon atom furthest from the former carbonyl atom becomes the chiral center
Questão 11
Questão
Which of these are carbohydrates that have a chemical structure that includes a six-membered ring consisting of five carbon atoms and one oxygen atom?
Questão 12
Questão
The disaccharide formed upon condesation of two glucose molecules via the 1-4 bond is called
Responda
-
Trehalose
-
Sucrose
-
Maltose
-
Lactose
Questão 13
Questão
Which of these describes cellobiose
Responda
-
α-D-glucopyranosyl-(1→2)-β-D-fructofuranoside
-
β-D-glucopyranosyl-(1→4)-β-D-glucopyranose
-
β-D-galactopyranosyl-(1→4)-α-D-glucopyranose
-
α-D-glucopyranosyl-(1→4)-β-D-glucopyranose
Questão 14
Questão
Polysaccharides...
Responda
-
can be branched but cannot have multiple monomer types
-
cannot be unbrached
-
have defined molecular weights
-
with only two monomer types cannot be branched
Questão 15
Questão
Which one of these hetero-polysaccharides has the largest size
Responda
-
peptidoglycan
-
agarose
-
hyaluronan
Questão 16
Questão
which of these is used in Algae cell walls
Responda
-
Peptidoglycan
-
hyaluronan
-
agarose
Questão 17
Questão
Glucose is stored in animals as
Responda
-
Glucagon
-
Glycogen
-
Glucose
-
Insulin
-
Starch
Questão 18
Questão
Glycogen is a polysaccharide in which glucose is joined by β-(1→4) linkages
Questão 19
Questão
Glycogen is a polysaccharide in which glucose is joined by α-(1→6) linkages
Questão 20
Questão
Which of the following is true
Responda
-
Amylose is the branched form of starch
-
α-amylase is a pancreatic enzyme that hydrolyses the α (1→4) linkages of starch
-
Glycogen has less α (1→4) linkages than starch
-
Glycogen has less α (1→6) linkages than starch
Questão 21
Questão
hydrolysis of cotton occurs
Responda
-
at the β (1→2) linkages of D-glucose
-
at the α (1→2) linkages of D-glucose
-
at the β (1→4) linkages of D-glucose
-
at the α (1→4) linkages of D-glucose
Questão 22
Questão
Which of the following is not true
Responda
-
Glycosidic bonds can freely rotate
-
more than 10^9 metric tonnes of cotton are produced/year
-
Starch can be coiled into a helical structure
-
Glycogen and amylopectin have only one reducing end
Questão 23
Questão
Which of these lack enzymes that can hydrolyse D-glucose β (1→4) linkages
Responda
-
Fungi
-
bacteria
-
termites
-
protozoa
Questão 24
Questão 25
Questão
Sephadex gels separate proteins by
Responda
-
size
-
charge
-
polarity
-
shape
Questão 26
Questão
Which of these would you find in the first fractions after size exclusion chromatography
Responda
-
acidic proteins
-
the smallest proteins
-
the largest proteins
-
basic proteins
Questão 27
Questão
which of these are homoglycans
Responda
-
Agar
-
Dextrans
-
Peptidoglycan
-
None
Questão 28
Questão
Which of these can be linked to epichlorohydrin in sephadex beaded gels
Responda
-
Agar
-
Agarose
-
Peptidoglycan
-
Dextran
Questão 29
Questão
Agar is a complex mixture of heteropolysaccharides containing modified
Responda
-
Glucose units
-
Mannose units
-
Fructose units
-
None of the above
Questão 30
Questão
Which of these is false
Responda
-
Agarose can be used for growing bacteria
-
Agarose is a component of bacterial cell walls
-
Agarose can be used for DNA separation
-
Agar is a component of seaweed cell walls
Questão 31
Questão
N-acetyl-galactosamine is a ___ epimer of N-acetyl-glucosamine
Questão 32
Questão
Where wold yo expect to find hyaluronate
Responda
-
ECM of Cartilage
-
Hair
-
Nails
-
Horns
Questão 33
Questão
Which one of these glycosaminoglycans acts as a lubricant?
Responda
-
Chondrotin-4-sulfate
-
keratan sulfate
-
heparin
-
hyaluronate
Questão 34
Questão
which one of the has approximately 50'000 disaccharides per chain
Responda
-
hyaluronate
-
keratan sulfate
-
heparin
-
chondrotin-4-sulfate
Questão 35
Questão
Which one of these glycosaminoglycans consists of [galactose β(1,4) Glc-NAc6S] repeating disaccharides
Responda
-
hyaluronate
-
chondrotin-4-sulfate
-
heparin
-
keratan sulfate
Questão 36
Questão
Which of these repeating disaccharides make dermantan sulfate?
Responda
-
glucaronic acid and N-acetylglucosamine
-
glucaronic acid and N-acetylgalctosamine-4-sulfate
-
Iduronic acid and N-acetylgalactosamine-4-sulfate
-
Iduronic acid and N-acetylglucosamine
Questão 37
Questão
The cabohydrate attached to a protein in a Glycoconjugate attaches via...
Questão 38
Questão
Which of the following most likely contains the most glycosylated proteins (Glycoproteins)
Responda
-
Humans
-
E.coli
-
Ebola virus
-
Cats
Questão 39
Questão
O linked oligosaccharides are linked through the N terminus of the amino acid
Questão 40
Questão
In glycoproteins, sugars are attached either to the amide nitrogen atom in the side chain of asparagine (termed an N-linkage) or to the oxygen atom in the side chain of serine or threonine (termed an O-linkage)
Questão 41
Questão
Glycophorin A is the most important attachment site for which of the following parasites in order to enter erythrocytes
Responda
-
Plasmodium falciparum
-
Chilomastix mesnili
-
Entamoeba coli
-
Entamoeba dispar
Questão 42
Questão
Which of these sulfated glycosaminoglycans are attached to a protein anchored to a membrane lipid?
Questão 43
Questão
NB! Select all which are functions of polysaccharides
Responda
-
Labelling of proteins for destruction
-
Recognition sites for growth factors
-
recognition sites for bacteria
-
localization of certain proteins
Questão 44
Questão
Which one of these is not a main component of the extracellular matrix (ECM)
Responda
-
Proteoglycan aggregates
-
Collagen fibers
-
Elastin
-
Fatty acids
Questão 45
Questão
Which one of these in not a characteristic of Glycosaminoglycans
Questão 46
Questão
Plasmodium flaciparum requires which of these as an attachment site to enter erythrocytes
Responda
-
Glycophorin A
-
Hyaluronan
-
syndecan
-
Podocalyxin
Questão 47
Questão
Which of these about proteoglycans is not true
Responda
-
Proteoglycan aggregates are found in articula cartilage
-
Proteoglycans influence growth factor activation and adhesion
-
glycosaminoglycans are linked to the core protein from the anomeric carbon
-
proteoglycanaggregates form high friction material
Questão 48
Questão
Which of these are integral receptors for extracellular proteoglycans
Responda
-
Integrins
-
actin
-
collagen fibers
-
elastin
Questão 49
Questão
Which of these about enzymatic reactions is true
Responda
-
Enzymes directly affect equilibrium (∆G)
-
Entropy cost is paid during binding
-
enzymes increse reaction rates (κ ) by increasing (∆G)
-
slow reactions do not have high activtaion barriers
Questão 50
Questão
Rate of enzymatic reactions are affected by....? (Click all true)
Questão 51
Questão
Which one of these describes a micelle
Responda
-
individual units are wedge shaped
-
artificial carriers of molecules
-
individual units are cylindrical
-
composed lipid-based structures that form pliable sheets
Questão 52
Questão
Which of these is false
Responda
-
membranes vary from 3-10nm
-
membranes form spontaneously by noncovalent forces
-
membranes are symmetric
-
membranes can be found within cells
Questão 53
Questão
Which of these is true about fatty acids
Responda
-
Most natural fatty acids are branched
-
Saturated fatty acids have double bonds between carbons in the chain
-
Most natural fatty acids have an even number of C's
-
linoleic acid is a saturated fatty acid
Questão 54
Questão
Which of these is false about fatty acids
Responda
-
Fatty acids solubility decreases as the chain length increases
-
Melting point decrases as the chain length decreses
-
Melting point increases as the number of double bonds increases
-
unsaturated cis fatty acids have a lower melting point than saturated fatty acids
Questão 55
Questão
Omega-3 (ω-3) fatty acids have
Responda
-
a double bond between the 2nd and 3th carbon from the methyl end of the chain.
-
a double bond between the 3rd and 4th carbon from the methyl end of the chain.
-
a double bond between the 1st and 2nd carbon from the methyl end of the chain.
-
a double bond between the 2nd and 3nd as well as 3rd and 4th carbon from the methyl end of the chain.
Questão 56
Questão
Which of these is untrue
Responda
-
Triacylglycerols are polar
-
Triacylglycerols are non hydrated
-
Vegetable oils are composed of triacylglycerols with unsaturated fatty acids
-
Animal fats are composed of triacylglycerols with saturated fatty acids
Questão 57
Questão
which of these is a greasy solid at room tempreature
Questão 58
Questão
which of these is a sphingolipid
Questão 59
Questão
Which of these is the head group of phosphatidylserine
Questão 60
Questão
Which of these has a net charge of -4 at pH7
Questão 61
Questão
Which of these is the major component of most eukaryotic cell membranes
Responda
-
phophatidylcholine
-
phosphatidylglycerol
-
cardiolipin
-
phosphatidylethanolamine
Questão 62
Questão
a fatty acid is joined to sphingosine via an
Responda
-
ester linkage
-
amide linkage
-
glycosidic linkage
-
phosphodiester linkage
Questão 63
Questão
ganglioside GM2 has which of these as a head group
Questão 64
Questão
The blood groups are determined in part by the
Questão 65
Questão
The structure of sugars located on the head groups in glycosphingolipids is determined by an expression of specific glycosyltransferases. Individuals with a glycosyltransferase that transfers an N-acetylgalactosamine group will
Responda
-
will have the O antigen
-
A blood group
-
B blood group
-
AB blood group
Questão 66
Questão
which of thes is false
Responda
-
Cholesterol modulates cell membrane fluidity
-
Mammals can not synthesize cholesterol
-
cholesterol in loe density lipoproteins tend to deposit in arteries
-
most bacteria lack sterols
Questão 67
Questão
which of these polyketides is an antibiotic
Responda
-
erythromycin
-
amphotericin B
-
lovastatin
Questão 68
Questão
which of these lipids are hormone precursors
Responda
-
vitamins E and K
-
vitamins A and D
-
steroid hormones
-
eicosanoids
Questão 69
Questão
which of these lipids are paracrine hormones
Responda
-
phosphatidylinositols
-
vitamins A and D
-
vitamins E and K
-
Dienes
-
eicosanoids
Questão 70
Questão
which of these is true
Responda
-
cholesterol is predominant in mitochondrial membranes
-
galactolipids are abundant in animals
-
membranes have non-selective import and export across the membrane
-
archaebacteria have monolayer instead of a bilayer
Questão 71
Questão
which of these is a type 6 integral membrane protein
Questão 72
Questão
Which of these amino acid residues would you find predominantly in the transmembrane segments of membrane proteins
Questão 73
Questão
Proteins can be targeted to the INNER leaflet of the plasma
membrane by farnesylation. The primary sequence of the protein contains a signature for farnesylation which is
Questão 74
Questão
hutchinson-gilford progeria syndrome is caused by
Responda
-
palmitoylation defect
-
myristoylation defect
-
farnesylation defect
Questão 75
Questão
which of these are only found on the outside of cell membranes
Responda
-
proteins
-
lipids
-
carbohydrates
Questão 76
Questão
which of these statements about the physical properties of membranes is true
Responda
-
Permeable to large polar solutes and ions
-
Not permeable to small polar solutes and nonpolar
compounds
-
Permeability can be artificially increased by chemical
treatment
-
Exist in a single phase and cannot undergo phase
transitions
Questão 77
Responda
-
cell membrane transition from the gel to fluid
-
cell membrane transition from the fluid to gel
-
cell membrane changed to become not permeable to large polar solutes
-
cell membrane changed to become permeable to small polar solutes and nonpolar compounds
Questão 78
Questão
Which of these statements on membrane fluidity is incorrect
Responda
-
is determined mainly by the fatty acid composition
-
more fluid membranes require shorter and more unsaturated fatty acids
-
At higher temperatures cells need more saturated fatty
acids to maintain fluidity
-
Gel phase means that the individual molecules do not move
around
Questão 79
Questão
which of these increase in membrane compisition percentage when temperatures increase
Responda
-
Myristic acid
-
palmitoleic acid
-
oleic acid
-
hydroxymyristic acid
Questão 80
Questão
Cell membranes of .... contain hopanols instead of sterols
Responda
-
animals
-
bacteria
-
plants
-
fungi
Questão 81
Questão
Membrane Dynamics: Transverse Diffusion.
Spontaneous flips of individual lipids from one leaflet to another are rare because...
Responda
-
the hydrophobic head group must transverse the hydrophilic tail region of the membrane
-
membrans are rigid and individual lipids cannot move at all
-
the charged head group must transverse the hydrophobic tail region of the membrane
Questão 82
Questão
Which is false about flippases
Responda
-
catalyze transverse diffusion
-
catalyze lateral diffusion
-
use ATP
-
move lipids against the concentratiion gradient
Questão 83
Questão
Tick ALL that are true!!
Responda
-
Membrane Lipid Rafts contain clusters of glycosphingolipids with longer-than-usual tails
-
Membrane Lipid Rafts are more ordered than the rest of the membrane
-
Membrane fusion can only occur through protein mediation
-
Passive diffuision of polar molecules across cell membranes has a high activation barrier
Questão 84
Questão
Which of these is a membrane receptor that detects light
Responda
-
opsin
-
insulin receptor
-
acetylcholine receptor
-
maltoporin
Questão 85
Questão
Which of these is a membrane receptor that detects neurotransmitters
Responda
-
opsin
-
acetylcholine receptor
-
maltoporin
-
insulin receptor
Questão 86
Questão
Cystic fibrosis (Mucoviscidose) is caused by
Responda
-
a mutation to a Cl- ion channel in epithelial cells
-
a mutation to a K+ ion channel in epithelial cells
-
a mutation to a Na+ ion channel in epithelial cells
-
a mutation to a Ca2+ ion channel in epithelial cells
Questão 87
Questão
Tick ALL that are correct
Responda
-
Energy of ATP hydrolysis can be used to drive protons through the membrane
-
Energy of the proton gradient can be used to synthesize ATP
-
Primary active transport is a form of active transport across a biological membrane in which a transporter protein couples the movement of an ion (typically Na+ or H+) down its electrochemical gradient to the uphill movement of another molecule or ion against a concentration/electrochemical gradient.
-
glucose is cotransported with Na+ in intestinal epithelial cells
Questão 88
Questão
Which of these plasma proteins is the most abundant
Responda
-
transferrin
-
ceruloplasmin
-
immunoglobulins
-
albumin
Questão 89
Questão
What is labelled as B?
Responda
-
blood
-
plasma
-
White blood cells
-
ficoli
Questão 90
Questão
What is labelled as D
Responda
-
Plasma
-
White blood cells
-
Ficoli
-
white blood cells
Questão 91
Questão
Which of these are not a hematopoietic cells
Responda
-
eosinophils
-
basophils
-
neutrophils
-
thrombocytes
Questão 92
Questão
Which of these is derived from lymphoid stem cells
Responda
-
erythrocytes
-
T cells
-
basophil
-
neutrophil
Questão 93
Questão
Which one of these leukocytes secretes histamine and mediates inflammation
Responda
-
neutrophils
-
basophils
-
eosinophils
-
macrophages
Questão 94
Questão
Which of these leukocytes produces Ab (antibodies)
Responda
-
Neutrophils
-
T cells
-
B cells
-
Macrophages
Questão 95
Questão
Where is myoglobin found
Responda
-
in the bone marrow
-
freely circulating in the blood
-
in skeletal and striated muscles
-
restricted to erythrocytes
Questão 96
Questão
which of these is false
Responda
-
myogloblin stores oxygen in the cytoplasm and delivers it to mitochondrion
-
hemoglobin is restricted to erythrocytes
-
Heme (B) is the oxygen binding molecule found only in hemoglobin
-
the distal histidine of the myglobin protein hydrogen bonds with oxygen bound to the protein
Questão 97
Questão
Consider a process in which a ligand (L) bind reversibly to a site in a protein (P). After some time, the process will reach equilibrium where the Ka (association rate constant) and Kd (dissociation rate constant) rates are equal. which of these equations represents the equilibrium.
Responda
-
kd [P].[L] = ka [PL]
-
ka [P].[L] = kd [PL]
-
[P].[L] = [PL]
-
ka [P].[L] > kd [PL]
Questão 98
Questão
Which of these statements is false
Responda
-
when the first binding event increases affinity at the remaining sites it is called positive cooperativity
-
when the first binding event decreases affinity at the remaining sites it is called negative cooperativity
-
oxygen binds to heme better than carbon monoxide
-
nH( hill coefficient) > 1 equals positive cooperativity
Questão 99
Questão
Cooperativity can be described as
Responda
-
positive homotropic regulation
-
negative homotropic regulation
-
positive heterotropic regulation
-
negative heterotropic regulation
Questão 100
Questão
Which of these statement on hemoglobin is false
Responda
-
oxygen binding triggers a tense to relaxed state conformational change
-
tense state has a higher affinity for oxgen than the relaxed state
-
conformational change from the T state to the R state invloves breaking ion pairs between the alpha1-beta2 interface of hemoglobin
-
2,3 -Bisphosphoglycerate is a negative heterotropic regulator of hemoglobin function
Questão 101
Questão
which of these is a non-phosphorylated nitrogenous base
Responda
-
nucleoside
-
nucleotide
-
nucleobase
-
nucleomide
Questão 102
Questão
Which side are the purines
Questão 103
Questão
Which color is encircling where a glycosidic bond between the nitrogenous base and the sugar would be present
Responda
-
red
-
green
-
blue
-
none of the above
Questão 104
Questão
Which letter represents deoxyadenylate
Questão 105
Questão
Which letter represents deoxythymidylate
Questão 106
Questão
Which letter represents deoxyguanylate
Questão 107
Questão
Which letter is representing cytidylate (CMP)
Questão 108
Questão
Which of these statements about the purine and pyrimidine bases is true
Questão 109
Questão
In nucleotides the pentose ring is attached to the nucleobase via a
Responda
-
β -N-Glycosidic Bond
-
α -N-Glycosidic Bond
-
Hydrogen bond
-
none of the above
Questão 110
Questão
In DNA structure there is free rotation about
Responda
-
C-1’-N-glycosyl bond
-
C-2’-N-glycosyl bond
-
C-3’-N-glycosyl bond
-
C-4’-N-glycosyl bond
Questão 111
Questão
How many base pairs do you find in the A form of DNA
Questão 112
Questão
The aromaticity of the nucleotide bases and their dipole moments is important for which interactions in DNA
Responda
-
Van der Waal forces in base stacking
-
link between base and sugar in a nucleotide
-
the link between two different nucleotides
-
interstrand bonding and complementarity
Questão 113
Questão
Figure A represents which type of DNA secondary structure
Responda
-
hairpin
-
mirror image
-
palindrome
-
cruciform
Questão 114
Questão
Figure C represents which type of DNA secondary structure
Responda
-
Cruciform
-
Palindrome
-
Hairpin
-
Mirror image
Questão 115
Questão
DNA sequences with a very high proportion of G residues forms which unusual DNA structure found on chromosome telomeres
Responda
-
tetraplex DNA
-
triplex DNA
-
inverted repeats
-
cruciforms
Questão 116
Questão
Which of these are a quaternary DNA structure
Responda
-
Chromatin
-
hairpin
-
supercoil
-
Triplex
Questão 117
Questão
In mammals ____ Functions as an autocoid, or "local hormone"
Responda
-
Adenosine
-
Guanine
-
Cytosine
-
Thymine
Questão 118
Questão
Which one of these is an RNase enzyme that prevents inbreeding of plants
Responda
-
S-RNase
-
RNase-P
-
Dicer
-
None of the above
Questão 119
Questão
_____ is an enzyme that cleaves double-stranded RNA into oligonucleotides
Questão 120
Questão
Why would animal cells need an enzyme that cleaves double-stranded RNA into oligonucleotides
Responda
-
processessing tRNA precursors
-
protection from viral genomes
-
using RNA as an energy source
-
using RNA in Coenzymes
Questão 121
Questão
RNA would be unstable in which of the conditions listed below