Quiz
Genetics
Perguntas do quiz (32)
1Of the following polymorphisms which are single nucleotide differences that are seen between two genomes?
- ARestriction fragment length polymorphisms
- BShort tandem repeats
- CVariable number tandem repeats
- DSingle nucleotide polymorphisms
- EChromosomal translocation
2Which of the following polymorphisms can be detected through Southern blot?
- AShort tandem repeats
- BSingle nucleotide polymorphisms
- CRestriction fragment length polymorphisms
- DLong interspersed nucleotide sequences
3What does it mean, that a locus is homozygous?
- Amany different alleles
- Btwo alleles that are the same
- Ctwo alleles that are different
- Dno alleles
- Eone allele have been deleted
4The following is a description of which method.
Patients DNA was isolated and cut with HaeIII. Product of the restriction digest was resolved by gel electrophoresis and transferred to a membrane. Then the membrane was exposed to hybridization probes, and the resulting band pattern was compared with that seen in another sample of DNA.- ARFLP by Southern blotting
- BVNTR by PCR
- CSNP by sequencing
- DSTR by PCR
- ESNP by Western Blot
5FGA, D8S1179, and D2S11 are examples of which of the following?
- ARFLP
- BVNTR
- CSTR
- DSNP
6Which of the following is used as a marker of gender?
- AD8S1179
- BAmelogenin
- CTPOX
- DPentaD
- ECD4
7How many loci are considered core loci by the Federal Bureau of Investigation in the Combined DNA Indexing System?
- A10
- B12
- C13
- D16
- E20
8When two sources of DNA are compared by STR analysis in a crime scene, how many differences between alleles will determine that the two sources are different?
- A1
- B2
- C4
- D6
- E25
9Which of the following polymorphisms can be used to compare DNA samples derived from males but not females?
- ASTR
- BY-STR
- CRFLP
- DVNTR
- ESNP
10Which of the following STRs is a Y-STR?
- AD5S818
- BvWA
- CPenta E
- DDYS385
- ELPL
11A child has disputed paternity. The child has the following STR haplotype:
TPOX = 7/8; D5S818 = 11/12; D13S317 = 9/10; vWA = 11/12; D21S11 = 27/28.
Alleged Father 1 has the following STR haplotype: TPOX = 6/10; D5S818 = 9/13; D13S317 = 9/14; vWA = 14/16; D21S11 = 30/33.
What can be said of Alleged Father 1?- AHe is the father of the child
- BHe cannot be excluded as the father
- CHe is excluded as the father.
- DMore STRs need to be analyzed before a conclusion can be made.
12An individual who has two populations of cells that were derived from two different zygotes is called a:
- Achimera
- Bmosaic
- Cheteroplasmy
- Dmutant
13A woman has been raped by an unknown man. Which of the following laboratory procedures can be used to more accurately analyze residual DNA left by the man in an effort to identify him?
- ARFLP
- BSTR
- CY-STR
- DVNTR
14DNA found at the scene of the crime was determined to have one peak at 212 bp at the amelogenin locus. The source of this DNA is which of the following?
- AFemale
- BMale
- CImpossible to tell from one locus
- DThis locus does not discriminate between males and females
15STR analysis is performed on bone marrow donor-recipient pairs prior to transplantation for which of the following reasons?
- ATo determine whether the donor and recipient are a match
- BTo determine the likelihood of graft-versus-host disease
- CTo find informative alleles for post-transplantation studies
- DTo add their STR haplotypes to a national database
16STR analysis was performed on a bone marrow donor and recipient pair with the following results. Which loci are informative?
- AvWA and TH01
- BTH01 and D13S317
- CD16S539 and F13A01
- DvWA and D13S317
17Bone marrow has been transplanted into a recipient. STR analysis was performed on whole blood from the recipient 6 months after the transplant by PCR, followed by capillary gel electrophoresis with fluorescence measurement of amplicons. For the TPOX locus, the donor and recipient do not share alleles. The fluorescence of the TPOX locus for the donor peak was 15693, and the fluorescence of the TPOX locus for the recipient peak was 5329. What is the percentage of recipient cells remaining?
- A25%
- B34%
- C66%
- D75%
18Two people have what percentage of DNA sequence that differs between them?
- A1%
- B5%
- C10%
- D25%
- E15%
19Two middle-age women who had been adopted into different families as infants discover circumstantially that they may have the same biological mother. Which of the following analyses would give the best information toward proving their maternal lineage?
- AY-STR
- BMitochondrial DNA
- CRFLP-PCR
- DSNP haplotypes
20Consider the following STR analysis:
Which of the child alleles are inherited form the father?
- AD3S1358: 15, vWA: 18, FGA: 24, TH01: 10 , TPOX: 11, CSF1PO: 12, D5S818: 12, D13S317: 9
- BD3S1358: 4, vWA: 5, FGA: 20, TH01: 11 , TPOX: 10, CSF1PO: 13, D5S818: 3, D13S317: 6
- CD3S1358: 15, vWA: 17, FGA: 23, TH01: 6 , TPOX: 11, CSF1PO: 12, D5S818: 10, D13S317: 10
- DD3S1358: 10, vWA: 17, FGA: 24, TH01: 6 , TPOX: 10, CSF1PO: 12, D5S818: 10, D13S317: 9
- ED3S1358: 15, vWA: 18, FGA: 24, TH01: 10 , TPOX: 11, CSF1PO: 12, D5S818: 12, D13S317: 10
21Basked on the results which of the alleged fathers (AF) is the father?
- AAF1
- BAF2
- CNeither
22A child and an alleged father (AF) share alleles with the following paternity index:
What is the combined paternity index from these three loci?
- A4.131
- B4.5
- C5
- D3.131
- A4.131
23With 50% prior odds, what is the probability of paternity from these three loci?
- A80%
- B76%
- C90%
- D60%
24What is a traditional definition of a polymorphism?
- AThe genets variation must be present in at least 1 % of the population.
- BThe genets variation must be present in at least 5 % of the population.
- CThe genets variation that no longer is present in the population.
- DThe genets variation can not be present in majority of the population.
25Which of the following genomic variations is the hardest to detect?
- ASNP
- BSTRs
- CVNTRs
- DRFLPs
26When comparing a generic similarity go two random individuals, what percentage of their genome is identical?
- A99.5%
- B95%
- C90%
- D100%
- E80%
27RFLP stands for?
- ARestriction fragment length polymorphism
- BRapidly Fusing length polymorphisms
- CRescue factor logical polymorphisms
- DRedundant fragment length polymorphism
28Closely linked markers are used for:
- AAccurate mapping of regions associated with phenotypic characteristics
- BFinding the length of a sequence
- CLocation of the centromere
- DDefining the promoter
- EDisabling the binding of transcription factors
29What is a definition of a haplotype?
- AA block of closely linked SPS on the same chromosome that tend to be inherited together.
- BA half of a chromosome.
- CChromosome with only one functioning allele.
- DAllele that gives a disfiguring phenotype.
30Mitochondrial DNA is____
- Acircular double stranded
- Bcircular single stranded
- Clinear double stranded
- Dlinear single stranded
31Genes encoded on the mtDNA include:
- A22 tRNA genes, 2 ribosomal RNA genes, and 12 genes coding for components of the oxidation-phosphorylation system.
- B30 tRNA genes, 2 ribosomal RNA genes, and 12 genes coding for components of the oxidation-phosphorylation system.
- C22 tRNA genes, 6 ribosomal RNA genes, and 12 genes coding for components of the oxidation-phosphorylation system.
- D22 tRNA genes, 2 ribosomal RNA genes, and 60 genes coding for components of the oxidation-phosphorylation system.
32Mitochondrial DNA follow which type of inheritance?
- AMaternal
- BPaternal
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