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Questions in this quiz (35)
1Anatomy (Nelsen)
The celiac ganglion is comprised of which of the following types of neuron cell bodies?- AVisceral afferent
- BSympathetic visceral efferent
- CParasympathetic visceral efferent
- DSomatic afferent
2Anatomy (Nelsen)
Which structure(s) contributes to mechanical digestion of food?- ALiver
- BMuscles of mastication
- CPancreas
- DSalivary glands
3Anatomy (Nelsen)
A 67-year-old man has severe cirrhosis of the liver, restricting blood flow through the liver from the portal venous system. You suspect that he may have enlarged veins where the portal and caval venous systems meet to compensate for this decreased portal blood flow. Which of the following pairs of veins form a portocaval anastomosis?- AInferior mesenteric and splenic veins
- BLeft colic and middle colic veins
- CRight colic and ileocolic veins
- DSuperior and inferior rectal veins
4Pathology (Heinrich)
Which of the following is the oncogenic target of the 8;14 translocation associated with Burkitt's lymphoma?- ABCR
- BIGH
- CMYC
- DABL
5Pathology (Heinrich)
Which is the best technique to demonstrate that a growth is clonal?- AFamily history
- BProtein expression
- CGene expression profiling (mRNA expression patterns)
- DDNA sequencing
6Histology (Planck)
Which portion of the respiratory system contains the smallest pieces of cartilage?- ABronchi
- BTrachea
- CBronchioles
- DAlveoli
7Histology (Planck)
What is the orientation of smooth muscle in the tunica media of large veins?- ACircumferential and/or helical
- BLongitudinal
- CAdjacent layers with inner circumferential and outer longitudinal
- DAdjacent layers with outer circumferential and inner longitudinal
8Histology (Planck)
Contraction of skeletal muscle is activated by the binding of calcium to which of the following?- ATroponin complex
- BTropomyosin
- CT-tubule
- DMyosin type II
9Planck-Histology
What part of the sarcoplasmic reticulum runs parallel to T tubules?- AJunctional fold
- BMotor end plate
- CSarcolemma
- DTerminal cisterna
10PurPyr (Hasne)
A predisposition to hyperuricemia and gouty arthritis can be caused by which of the following?- AReduced activity of PRPP synthetase
- BReduced activity of Xanthine oxidase
- CReduced activity of Hypoxanthine-guanine phosphoribosyltransferase
- DReduced activity of PRPP amidotransferase
11PurPyr (Hasne)
In de novo synthesis, the pyrimidine ring is assembled using which of the following?:- Aasparagine
- Bglutamic acid
- Cglycine
- Dbicarbonate and NH3 from glutamine
12PurPyr (Hasne)
A tetrahydrofolate derivative is required for which of the following?:- ADe novo synthesis of pyrimidines
- BThe synthesis of thymine-containing nucleotides from uracil-containing nucleotides
- CThe synthesis of xanthine from purine nucleotides
- DThe cleavage of the purine ring in uric acid by an enzyme in the human liver
13PI3 (McCormick)
Insulin stimulates glucose uptake into fat and muscle cells by stimulating the insulin-sensitive glucose transporter, Glut 4. It does this by activating phosphoinositide 3-kinase (PI3K), which subsequently activates the protein kinase Akt2. How does activated Akt2 increase glucose transport by Glut4?- AAkt2 directly phosphorylates Glut4, which increases Glut4 activity
- BAkt2 alters the affinity (Km) of Glut4 for glucose
- CAkt2 stimulates transcription of the Glut4 gene
- DAkt2 increases Glut4 plasma membrane abundance
14PI3 (McCormick)
How does the second messenger PI(3,4,5)P3, generated by phosphoinositide 3 kinase (PI3K), activate the protein kinase Akt?- ABy directly modifying the conformation of the catalytic pocket of Akt
- BBy activating the protein kinase mTORC1, which phosphorylates Akt
- CBy recruiting it to the plasma membrane, where it is activated by phosphoinositide dependent kinase 1 (PDK1)
- DBy inactivating activity of the lipid phosphatase PTEN
15OncoCCApo
Which one of the following proteins is primarily responsible for the ability of cilia to beat?- AMyosin
- BDynein
- CKinesin
- DActin
16OncoCCApo
Extrinsic apoptosis can be induced in which of the following ways?:- ASecreted ligands
- BDNA damage
- CTP53
- DpRB
17OncoCCApo
What is the kinetochore?- AA component of the centrosome
- BA protein complex associated with the centromere
- CPart of the nuclear envelope
- DA component of the cell's proteolysis machinery
18OncoCCApo
The MAP kinase cascade induces gene expression in which of the following ways?- APhosphorylating transcription factors
- BActivating RAS
- CPhosphorylating receptor tyrosine kinases
- DCausing chromosomal rearrangements
19NucRec (McCormick)
The glucocorticoid hormone cortisol exerts its effects by binding to the Glucocorticoid Receptor (GR), a Type I nuclear receptor. In common with other hormones that bind to and activate nuclear receptors, a key feature of cortisol signaling is which of the following?- ACortisol has a short-half in the circulation
- BSignal amplification through GR is high
- CCortisol has a long duration of effect
- DThe primary receptor for cortisol is at the plasma membrane
20NucRec (McCormick)
A 25 year old woman presents with unexplained fatigue and weight gain. She is found to have increased blood cholesterol levels and her levels of thyroid stimulating hormone are 10mU/L, consistent with a diagnosis of hypothyroidism. Triiodothyronine (T3), the most active form of thyroid hormone, exerts its actions by which mechanism?- ABy binding to a cytoplasmic receptor, leading to dissociation of the receptor from Heat Shock Protein 90 (Hsp90), translocation into the nucleus,
and alteration of gene transcription - BBy binding to a plasma membrane receptor that activates phospholipase C, leading to cleavage of the phospholipid PI(4,5)P2 to diacyl glycerol
(DAG) and inositol 1,4,5 trisphosphate (IP3) - CBy binding to a receptor that is always bound to genomic DNA, activating gene transcription by causing an exchange of repressors for activators
- DBy binding to a plasma membrane receptor that activates a kinase cascade that ends with phosphorylation of the kinase ERK1, which
translocates to the nucleus where it phosphorylates targets
- ABy binding to a cytoplasmic receptor, leading to dissociation of the receptor from Heat Shock Protein 90 (Hsp90), translocation into the nucleus,
21Hox (Schnapp)
Which of the following best describes Hox gene loci in the human genome?- AEvery chromosome contains 9-12 unlinked Hox genes.
- BEvery chromosome contains a Hox gene complex of 9-12 linked Hox genes.
- CA subset of chromosomes contain 9-12 unlinked Hox genes.
- DA subset of chromosomes contain a Hox gene complex of 9-12 linked Hox genes.
22G proteins (Farrens)
You are interested in cell-size regulation and discover that signaling through a GPCR called JOE1 is important in controlling cell size in embryonic rat cells. The G protein downstream of JOE1 activates adenylyl cyclase, which ultimately leads to the activation of PKA. You discover that cells that lack JOE1 are 15% smaller than normal cells, while cells that express a mutant, constitutively activated version of PKA are 15% larger than normal cells. Given these results, which of the following treatments to embryonic rat cells should lead to smaller cells?- AAddition of a drug that causes cyclic AMP phosphodiesterase to be hyperactive.
- BAddition of a drug that prevents GTP hydrolysis by Ga
- CAddition of a drug that activates adenylyl cyclase
- DAddition of a drug that mimics the agonist of JOE1
23G proteins (Farrens)
GPCRs activate G-proteins by stimulating which of the following Ga functions?- AGTPase activity
- BMyristolation
- CGDP - GTP exchange
- DReassociation with Ga
24Epi part 2 (Stull)
Which of the attached 2x2 table illustrates the epidemiology world-view that you should always keep in mind when you organize an epidemiologic study design?
- AA
- BB
- CC
- DD
25Epi part 2 (Stull)
While evaluating a patient in the ED for chest pain, your preceptor obtains a D-Dimer test, and tells you she uses this test because it has over 95% sensitivity for pulmonary embolus. By sensitivity she means which of the following ?- AOver 95% of the patients with a positive test will have the disease.
- BOver 95% of the people with a negative test will not have the disease.
- COver 95% of people who have the disease will have a positive test.
- DOver 95% of people who do not have the disease will have a negative test.
26DevBiol (Schnapp)
Which of the following is a defining feature of the transit amplifying progenitor cells in the small intestine?- AMore quiescent than the stem cells (i.e. they divide less frequently than the stem cells)
- BSelf-renew for the life of the organism
- CLess quiescent than the stem cells (i.e. they divide more frequently than the stem cells)
- DReside beneath (basal to) the basement membrane, outside the epithelium
27DevBiol (Schnapp)
Cells within which of the following tissues turn over least frequently (or not at all) in adults?- ABlood
- BGastric mucosa
- CEpidermis
- DCentral nervous system
28Conf Priv (Coleman)
Privacy refers to the sanctity of a person's body. Proper draping prior to a physical examination is one means of respecting a person's privacy. Which of the following is another way to help provide privacy?- AShredding all documents which contain a person's protected health information (PHI).
- BEnsuring that computer workstations in public areas are secured when not in use.
- CEnsuring that hospital room doors are closed during morning team rounds.
- DNot discussing patient care issues in public places, such as hospital elevators.
29Conf Priv (Coleman)
Confidentiality refers to protecting a patient's health information. Which one of the following scenarios best exemplifies a breach of
confidentiality?- AA medical assistant goes to the clinic waiting area, which is full of people, and loudly calls for the next patient, "Mike?" Two men who are not
together stand up. The medical assistant says. "Mike D?" - BAfter an appointment, a patient follows a medical resident out of the exam room into the hallway, and asks a question about their treatment plan.
The resident brings the patient back into the exam room, and closes the door. - CAn adolescent patient and his mom visit their family physician who they have known since the patient was a toddler. The doctor asks the parent
of the patient to wait in the hall while they finish taking a history. - DA doctor phones the number listed in the patient's electronic medical record, and gets a voice message system that does not identify the patient
by name. She leaves a voice message: "This is doctor ___. Good News! Your test results were all negative."
- AA medical assistant goes to the clinic waiting area, which is full of people, and loudly calls for the next patient, "Mike?" Two men who are not
30Cell Comm (Tyner)
The specificity of a receptor refers to which of the following?:- AThe ability of a receptor to bind only one type or a limited number of structurally related types of ligands
- BThe strength with which a ligand binds to its receptor
- CThe ability of different molecules very similar in structure to compete with each other to combine with the same receptor
- DThe degree to which receptors are occupied by ligands
31Cell Comm (Tyner)
Following binding of a ligand by a receptor tyrosine kinase, which of the following occurs?- AThe receptor tyrosine kinase will invert across the plasma membrane causing recruitment of downstream intracellular signaling substrates.
- BThe receptor tyrosine kinase will dimerize resulting in activation of the kinase domains and recruitment and phosphorylation of downstream
intracellular signaling substrates. - CThe receptor tyrosine kinase will exchange GDP for GTP allowing downstream pathways to become activated.
- DThe ligand will be transported across the plasma membrane by the receptor tyrosine kinase, allowing the ligand to activate intracellular
downstream signaling pathways.
32Cancer (Heinrich)
In the case of KRAS, activating mutations result in which change of protein function?:- AIncreased KRAS trafficking to the mitochondria
- BIncreased KRAS trafficking to the plasma membrane
- CIncreased KRAS tyrosine kinase activity
- DLoss of KRAS GTPase activity
33Abd Exam
On exam, which of the following indicates ascites fluid?- AMurphy's Sign
- BShifting dullness
- CObturator sign
- DRovsing's sign
34Abd Exam
In your small groups, the order recommend for examining the abdomen is which of the following?- AInspection, palpation, percussion, auscultation
- BPercussion, palpation auscultation, inspection
- CAuscultation, inspection, palpation, percussion
- DInspection, auscultation, percussion, palpation
35Hox (Schnapp)
Which of the following best describes the phenotype of a mutation in a Hox gene?- AThe phenotype of a Hox gene mutation is always a homeotic transformation.
- BThe phenotype of a Hox gene mutation can be a homeotic transformation or some other type of patterning defect.
- COnly in flies can Hox gene mutations lead to homeotic transformations.
- DOnly loss of function Hox gene mutations can lead to homeotic transformations.
Information
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- Quiz on W6 Questions, created by Madi Egan on 12/10/2018.
- Author
- Madi Egan
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