Quiz
Iron in Health and Disease
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Questions in this quiz (26)
1Forms of iron:
Ferric = [blank_start]Fe3+[blank_end]
Ferrous = [blank_start]Fe2+[blank_end]- AFe2+
- BFe3+
2There is no mechanism for iron excretion.
- ATrue
- BFalse
3Approximately [blank_start]1[blank_end]mg of iron is absorbed by the body per day.
- A1
4Iron absorption occurs mainly in which part of the small bowel?
The [blank_start]duodenum[blank_end]- Aduodenum
5Iron absorption is decreased by alcohol consumption.
- ATrue
- BFalse
6Duodenal cytochrome B, found in the luminal surface, is responsible for [blank_start]reducing[blank_end] [blank_start]ferric[blank_end] iron to [blank_start]ferrous[blank_end] iron
- Aferrous
- Bferric
- Cferric
- Dferrous
- Ereducing
- Foxidising
7[blank_start]Hepcidin[blank_end] is the main regulator of iron absorption. In cases of haemochromatosis, this structure binds to ferroportin and causes its degradation, thus disabling the transfer of iron to transferrin
- AHepcidin
8Assessment of body iron levels:
[blank_start]Functional Iron[blank_end] = Measure Haemoglobin concentration
[blank_start]Transport Iron[blank_end] = Measure % saturation of transferrin with iron
[blank_start]Storage Iron[blank_end] = Measure serum ferritin- AStorage Iron
- BTransport Iron
- CFunctional Iron
- DRegulated Iron
9Transferrin has [blank_start]2[blank_end] binding sites for iron
- A2
- B4
- C6
- D8
10[blank_start]Holotransferrin[blank_end] = Transferrin bound to iron
[blank_start]Apotransferrin[blank_end] = Transferrin not bound to iron- AHolotransferrin
- BApotransferrin
11Ferritin can store up to 4000 [blank_start]ferric[blank_end] ions
- Aferric
- Bferrous
12Which 4 of the follows factors can increase serum ferritin?
- AInflammation
- BSepsis
- CMalignancy
- DLiver injury
- EKidney Injury
- FHypoxia
- GAnaemia
13Name this clinical sign which can occur due to iron deficiency.
[blank_start]Koilonychia[blank_end]
- AKoilonychia
14Iron deficiency can also cause inflammation and scarring of the corner of the mouth.
This sign is called [blank_start]angular stomatitis[blank_end]- Aangular stomatitis
15Iron deficiency causes a [blank_start]microcytic[blank_end] anaemia
- Amicrocytic
- Bmacrocytic
16There are greater requirements for iron in [blank_start]women and children[blank_end] thus they are more likely to develop iron deficiency.
- Awomen and children
- Bwomen
- Cmen
- Dmen and children
17As well as poor dietary intake, which of the following can also cause iron deficiency anaemia?
- AMenorrhagia
- BGastric Ulcers
- CNSAIDs
- DHaematuria
- ECoeliac Disease
- FUlcerative Colitis
18The two types of haemochromatosis are primary and secondary:
[blank_start]Secondary[blank_end] haemochromatosis usually is the result of transfusions or iron loading anaemias.
[blank_start]Primary[blank_end] haemochromatosis is caused by a defect in the genes that control how much iron you absorb from food.- ASecondary
- BPrimary
19Hereditary Haemochromatosis is a primary haemochromatosis that typically arises due to a mutation of the HFE gene causing a decreased synthesis of which regulative protein?
[blank_start]Hepcidin[blank_end]- AHepcidin
20Haemochromatosis can cause erectile dysfunction in males
- ATrue
- BFalse
21Which three of the following can be caused by haemochromatosis?
- AWeakness/fatigue
- BJoint pains
- CCirrhosis
- DHypothyroidism
- ECluster headaches
- FTrigeminal neuralgia
22Hereditary Haemochromatosis most commonly occurs due to mutations in the [blank_start]HFE[blank_end] gene
- AHFE
23The initial treatment of choice for hereditary haemochromatosis in non-anaemic individuals is weekly [blank_start]venesection[blank_end]
- Avenesection
24The most common cause of death for those suffering from Hereditary Haemochromatosis is ...
- ADiabetes
- BHepatoma
- CCardiac Failure
25Secondary Iron Overload should be treated with weekly venesection.
- ATrue
- BFalse
26Primary Iron Overload. E.g. [blank_start]Hereditary Haemochromatosis[blank_end]. Should be treated with [blank_start]weekly venesection[blank_end]
Secondary Iron Overload. E.g. [blank_start]Thalassaemia/Transfusion[blank_end]. Should be treated with [blank_start]iron chelating agents[blank_end]- Aweekly venesection
- Biron chelating agents
- CThalassaemia/Transfusion
- DHereditary Haemochromatosis
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- Honours Degree Medicine (Haematology - Week 1) Quiz on Iron in Health and Disease, created by Matthew Coulson on 02/03/2019.
- Author
- Matthew Coulson
- Language
- English
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