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L12 Non-linear kinetics

Mer Scott 6 questions

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Questions in this quiz (6)

  1. 1The change in plasma [blank_start]concentration[blank_end] due to absorption, distribution, metabolism, or excretion is proportional to dose [blank_start]only[blank_end] if the pharmacokinetics are [blank_start]linear[blank_end]. This refers to [blank_start]first[blank_end] order processes.
    Non-linear/[blank_start]zero[blank_end] order processes occur usually because of [blank_start]saturation[blank_end] of carrier-mediated processes. AUC will be disproportional to the [blank_start]dose[blank_end] and the steady state concentration will be disproportional to the [blank_start]dosing rate[blank_end].
    1. Aconcentration
    2. Bonly
    3. Clinear
    4. Dfirst
    5. Ezero
    6. Fsaturation
    7. Gdose
    8. Hdosing rate
  2. 2Michaelis-Menten kinetics describes drug concentrations when the [blank_start]enzymes[blank_end] responsible for drug metabolism/elimination become saturated, and the [blank_start]maximum[blank_end] rate of metabolism (Vmax) for the drug is approached. Km is the [blank_start]serum concentration[blank_end] at which the rate of metabolism equals [blank_start]half[blank_end] of Vmax.
    1. Aenzymes
    2. Bmaximum
    3. Cserum concentration
    4. Dhalf
  3. 3The value of Km is useful because non-[blank_start]linearity[blank_end] is usually ‘visible’ when the concentration of the drug is [blank_start]larger[blank_end] than Km.
    The equation for observing the rate of a saturable process/one with MM kinetics is:
    rate (v) = ([blank_start]Vmax x C[blank_end]) / ([blank_start]Km + C[blank_end])
    1. Alarger
    2. Blinearity
    3. CVmax x C
    4. DKm + C
  4. 4We can determine the maintenance dose for a saturable process using the parameters of MM kinetics. The equation is:
    1. AMD = (Km + Css) / (Vmax x Css)
    2. BMD = (Vmax x Css) / (Km + Css)
  5. 5When C is less than Km, elimination follows first-order kinetics.
    1. ATrue
    2. BFalse
  6. 6Some drugs have ‘time-dependent’ non-linear metabolism. Instead of [blank_start]clearance[blank_end] changing with a change in dose or concentration, clearance changes with [blank_start]time[blank_end]. A notable example is [blank_start]carbamazepine[blank_end], which undergoes auto-induction. The clinical implications of this are that starting with the [blank_start]MD[blank_end] will result in [blank_start]toxic[blank_end] concentrations (causing drowsiness, tachycardia, coma).
    1. Aclearance
    2. Btime
    3. Ccarbamazepine
    4. DMD
    5. Etoxic

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Description
PHCY310 Quiz on L12 Non-linear kinetics, created by Mer Scott on 08/04/2019.
Author
Mer Scott
Language
English
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6
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phcy310
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