How is tyrosine kinase kept inactive when a ligand is not bound?

The activation lip hides the active site

The active site is phosphorylated and inactive

Once the activation lip is phosphorylated, what happens?

Phosphorylation continues of tyrosine kinase

Proteins bind to phosphorylated areas

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1Epidermal Growth Factors are 53aa long, with an Mr of 40,000
1. ATrue
2. BFalse
2What happens when you increase ornithine carboxylase and polyamine concentrations?
1. ACell division increases
2. BCell division decreases
3In general effects ( inc glucose/aa transport and inc Na/K ATPase activity) what hormone are growth factors most like?
1. AInsulin
2. BGlucagon
3. CVasopressin
4. DNO
4Increase Na+/H+ pump activity causes what?
1. AAlkylysation of the cytoplasm
2. BInc. DNA synthesis/mitosis
3. CInc protein production
5How is tyrosine kinase kept inactive when a ligand is not bound?
1. AThe activation lip hides the active site
2. BThe active site is phosphorylated and inactive
3. CA pseudosubstrate is bound
6What form does inactive tyrosine kinase stay in?
1. AMonomer
2. BDimer
3. CMultimeric group
7What effect does ligand binding have to tyrosine kinase?
1. APartial activation
2. BDimerisation
3. CMonomerisation
4. DFull activation
8Once the activation lip is phosphorylated, what happens?
1. APhosphorylation continues of tyrosine kinase
2. BBecomes fully active
3. CBecomes partially active
4. DProteins bind to phosphorylated areas
9Which of the following binds to phosphorylated tyrosine kinase?
1. AGRB2
2. BRAs
3. CGEF

Description: Structural Basis for Biological Function (Basics) Quiz on Growth Factors, created by gina_evans0312 on 04/11/2013.
Author: gina_evans0312
Language: English
Views: 584
Tags: basics structural basis for biological function structural basis for biological function basics
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