Assessment 1.4

1. 1Which of the following statements regarding drug metabolizing enzymes is true?

   1. ASubstrates for theses enzymes are usually endogenous biomolecules
   2. BThey are closely regulated through biofeedback
   3. CThey include a family of enzymes that has a wide substrate capacity
   4. DThey have a high specificity and efficiency
2. 2Which of the following characteristics are associated with phase I drug metabolism reaction?

   1. AA functional group is formed or revealed
   2. BThe metabolite is rarely active
   3. CA bio molecule is added to an existing functional group
   4. DThe drug is usually more lipid soluble
3. 3A drug interaction between clopidogrel/Plavix and omeprazole/Prilosec occurs because:

   1. AOmeprazole inhibits the metabolism of clopidogrel and increases the amount of active drug
   2. BOmeprazole inhibits the metabolism of clopidogrel and decreases activation of clopidogrel to its active metabolite
   3. COmeprazole induces the metabolism of clopidogrel and decreases activation of clopidogrel to its active metabolite
   4. DOmeprazole induces the metabolism of clopidogrel and decreases the amount of active drug
4. 4The most common Phase II reaction is

   1. ASulfation
   2. BN-dealkylation
   3. CEster Hydrolysis
   4. DGlururonidation
5. 5Which of the following drugs is an inhibitor of the CYP3A4?

   1. APhenobarbital
   2. BRifampin
   3. CKetoconazole
   4. DWarfarin
6. 6Which of the following types of metabolism is deficient in the elderly?

   1. AEster Hydrolysis
   2. BCYP450 oxidation
   3. CGlucuronidation
   4. DN-Acetylation
7. 7Which of the following isoforms is important in the activation of environmental chemicals?

   1. ACYP2C9
   2. BCYP3A4
   3. CCYP2E1
   4. DCYP2D6
8. 8All of the following parameters could affect the rate or extent of the drug metabolism EXCEPT:

   1. APharmacokinetics
   2. BGender
   3. CNutritional
   4. DReceptor binding
9. 9Glutathione conjugation is different from other Phase II reactions in that:

   1. AGlutathione conjugates are often active metabolites
   2. BGlutathione reacts with potentially toxic electrophilic compounds
   3. CThe glutathione conjugate is easily excreted in the bile or the urine
   4. DGlutathione requires bioactivation to make it react with the drug molecules
10. 10Which of the following isoforms is generally associated with induction

    1. ACYP2C9
    2. BCYP2D6
    3. CCYP3A4
    4. DAll of the above

11. 11Enalapril is the prodrug ester of the enalaprilat and it is converted to the enalaprilat by an esterase. Enalapril is used to lower blood pressure.
    A newly described esterase inhibitor, nargingen, has been identified in grapefruit juice. If "patient Q" is stable on 10 mg of Enalapril and they add a daily glass of grapefruit juice to their diet, what would happen?

    1. AThe patient would have no change in blood pressure
    2. BThe patient would have an increased lowering of their blood pressure or other toxic effect
    3. CThe patient would have a decreased lowering of their blood pressure
12. 12Which of the following drugs has significant first pass metabolism?

    1. AWarfarin
    2. BRifampin
    3. COmeprazole
    4. DOrganic Nitrates
13. 13Which of the following is the location where lipophilic drugs are metabolized?

    1. ANucleolus
    2. BSmooth ER
    3. CNucleus
    4. DSecretory Vesicles
    5. ERough ER
14. 14Lysosomes contain enzymes for

    1. Asynthesizing mRNA
    2. Baerobic production of ATP
    3. Cintracellular digestion
    4. Dglycosylation
15. 15The process of release of a neurotransmitter from a secretory vesicle is an example of

    1. Aendocytosis
    2. Bexocytosis
    3. Csecondary active transport
    4. Dprimary active transport
16. 16The reuptake of norepinephrine or serotonin into a neuron is an example of

    1. Aprimary active transport
    2. Bexocytosis
    3. Csecondary active transport
    4. Dendocytosis
17. 17For translation/synthesis of integral membrane proteins, ribosomes

    1. AAttach to the rough ER soon after the start of translation
    2. BDetach from the golgi apparatus to start translation
    3. CDisassembles in order to push the protein into the membrane
    4. DTranslate the protein directly into the cytosol
18. 18A typical fat consist of a

    1. Aglycerol backbone and three fatty acid side chains
    2. Bsphinogosine backbone and three fatty acid side chains
    3. Cglycerol backbone and two fatty acid side chains
    4. Dsphinogosine backbone and two fatty acid side chains
19. 19The phosphate -containing portions of phospholipids in aqueous solution face

    1. Athe outer surface of a monolayer
    2. Bthe core of a micelle
    3. Cthe core of the bilayer
    4. Dthe inner and outer surface of a bilayer
    5. Ethe outer surface of a micelle

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Assessment 1.4 Quiz on Assessment 1.4, created by AmberRose on 03/09/2015.

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