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Clinical Immunology - Transplant Immunology MCQs and Fill in the Blanks
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Questions in this quiz (25)
1An graft is a graft from one place to another in the same individual:
- ATrue
- BIncorrect
2Should blood group compatibility between donor and recipient be determined prior to kidney transplantation:
- AYes
- BNo
3Classical MHC class II genes (HLA-DR, DQ) have a more limited
distribution than MHC class I antigens:- AYes
- BNo
4The most suitable cells for HLA-compatibility testing are lymphocytes obtained from the patient's peripheral blood:
- AYes
- BNo
5Following blood transfusions, pregnancy or previous transplants, circulating antibodies may develop:
- AYes
- BNo
6The acute reaction of rejection of the transplanted organ is
manifested:- AIntraoperatively or immediately after surgery
- B24h up to 72h after transplantation
- CAfter 6 months
- DUp to 3 months
- EAll answers are correct
7In transplantation, preformed cytotoxic antibodies in the recipient:
- ACause graft rejection in a delayed type
- BAre responsible for the over-rejection
- CDo not result in graft rejection
- DCan be directed against HLA or ABO graft antigens
- EAll answers are correct
8Graft-versus-host disease (GVH) reaction:
- AManifests itself in differences in MHC antigens between donor and recipient
- BMay be the result of infusion of blood products containing viable lymphocytes into an immunologically incompetent recipient
- CRequires suppressor T-lymphocytes
- DAll answers are correct
- EThere is no correct answer
9Transplant rejection is a manifestation of:
- ACell-mediated immunity
- BType III hypersensitivity (immune complexes)
- CComplement-dependent cytotoxicity
- DAll answers are correct
- EThere is no correct answer
10Immunological follow-up of an organ transplant patient requires
examination of:- AChanges in lymphocyte populations and subpopulations
- BSerum cytokine levels
- CDonor-specific antibodies
- DAll of the above
- EThere is no correct answer
11In recipients with repeated kidney transplants, graft survival compared to recipients with first kidney transplantation is:
- AReduced
- BIncreased
- CThe same
- DAll the listed options are possible
- EThere is no correct answer
12Prevention of hemolytic disease of the newborn due to incompatibility with maternal Rhesus (RhD) factor includes:
- APassive immunization of the newborn to remove Rh antigen
- BPassive immunization of the mother to remove Rh antigen
- CPassive maternal immunization to produce anti-Rh IgG
- DUse of steroids to reduce maternal immune reactivity
13If the mother develops IgG antibodies to the A and B erythrocyte antigens of the fetus, hemolytic disease of the newborn will occur in children from:
- AAB mother and O father
- BO mother and AB father
- CA mother and A father
- DO mother and O father
- EAB mother and AB father
14Which of the following antigens are rich in B-lymphocyte cell
membranes:- AClass I MHC antigens
- BClass II MHC antigens
- CClass III MHC antigens
- DHLA-B antigens
- EComplement-activating antigens
15Class III MHC regions in the Main Tissue Compatibility Complex in humans contain genes that encode:
- AHLA -A, -B and -C molecules
- BHLA-DR, -DQ molecules
- CComponents of the complement system
- DHeat shock proteins and cytokines
- EThere is no correct answer
16Antimetabolites that suppress the immune response are the purine antagonists [blank_start]AZATIOPRINE[blank_end], [blank_start]MERCAPTOPURINE[blank_end].
- AAZATIOPRINE
- BMERCAPTOPURINE
17Hypergraft rejection is associated with [blank_start]REFORMED CYTOTOXIC ANTIBODIES[blank_end].
- AREFORMED CYTOTOXIC ANTIBODIES
18Accelerated rejection reaction takes place with the participation of these immunological factors and mechanisms [blank_start]sensitized[blank_end] T cells, [blank_start]preformed HLA[blank_end] antibodies formed during the [blank_start]graft[blank_end] and / or [blank_start]ADCC[blank_end].
- Asensitized
- Bpreformed HLA
- Cgraft
- DADCC
19Molecular genetic methods for HLA typing in clinical transplantation practice include [blank_start]PCR[blank_end].
- APCR
20Graft-infiltrating cells in the acute rejection reaction are predominantly?
Answer: [blank_start]CD4 T LYMPHOCYTES[blank_end].- ACD4 T LYMPHOCYTES
21Allogeneic transplantation?
Answer: Bone marrow transplantation from [blank_start]mother[blank_end] to [blank_start]daughter[blank_end]- Amother
- Bdaughter
22Autologous transplantation?
Answer: Skin grafting from a poor person to the [blank_start]same[blank_end] individual- Asame
23Syngenna?
Answer: Bone marrow transplantation between [blank_start]twins[blank_end]- Atwins
24Sources of stem cells?
Answer:
1. [blank_start]Bone marrow[blank_end]
2. [blank_start]Peripheral blood[blank_end]
3. [blank_start]Umbilical cord blood[blank_end]- AUmbilical cord blood
- BPeripheral blood
- CBone marrow
25Gene loci of the HLA II region?
Answer: [blank_start]DQ[blank_end] and [blank_start]DR[blank_end]- ADR
- BDQ
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- Description
- A2 clinical immunology Quiz on Clinical Immunology - Transplant Immunology MCQs and Fill in the Blanks, created by suyog gurung on 17/06/2022.
- Author
- suyog gurung
- Language
- English
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- 87
- History
- Created on 17 Jun 2022 · updated on 17 Jun 2022
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