Genetic Mapping

Description

Year 2 Quiz on Genetic Mapping, created by gina_evans0312 on 26/12/2013.
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Quiz by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 over 10 years ago
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Resource summary

Question 1

Question
What does genetic mapping rely on?
Answer
  • Inheritence phenotypes
  • Polymorphic Markers

Question 2

Question
How is the tracing of inheritence phenotypes done?
Answer
  • Genetic markers i.e. SNP's
  • Allele complimentation
  • Meiotic Tests

Question 3

Question
1cM =
Answer
  • 1% recombination
  • 10% recombination
  • 1kB
  • 10kB

Question 4

Question
How are physical maps made?
Answer
  • Design markers that overlap along the genome
  • Orientation of homologous chromosomes
  • Allele studies

Question 5

Question
Physical maps must be made of physically isolated parts of the genome
Answer
  • True
  • False

Question 6

Question
A genetic marker acts as a reference point in a linkage study
Answer
  • True
  • False

Question 7

Question
Genes are usually used as markers in non-human studies. Why can they not be used in humans?
Answer
  • Human genes are more unstable
  • Human genes vary too much
  • Human genes are more highly conserved

Question 8

Question
What is the preferred form of marker in humans?
Answer
  • Polymorphic introns
  • Polymorphic Exons
  • SNP's

Question 9

Question
More polymorphic DNA= less useful
Answer
  • True
  • False

Question 10

Question
Homozygotes are more useful in genetic mapping than heterozygotes
Answer
  • True
  • False

Question 11

Question
How must markers be placed along the chromosome?
Answer
  • Evenly spaced
  • As lightly as possibly
  • As densely as possible

Question 12

Question
The aim it to combine genetic and physical maps
Answer
  • True
  • False

Question 13

Question
Once you have a marker with a high linkage to a disease/trait, how do you use the physical map?
Answer
  • Find the marker and look for genes very close to it
  • Find the suspect gene and look for markers very close to it
  • Find the marker and look for genes as far away as possible

Question 14

Question
Which of the following are evenly distributed?
Answer
  • SNP's
  • Minisatellites
  • Microsatellites
  • RFLP's

Question 15

Question
Microsatellites are highly polymorphic
Answer
  • True
  • False

Question 16

Question
Which of the following are most useful as markers?
Answer
  • RFLP's
  • Minisatellites
  • Microsetellites
  • SNP's

Question 17

Question
There are two alleles (usually) for RFLP's
Answer
  • True
  • False

Question 18

Question
How are minisatellites typed?
Answer
  • Southern Hybridisation
  • Gel Electrophoresis
  • PCR

Question 19

Question
There are more than 10^10 SNP's in the human genome
Answer
  • True
  • False
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