Beta Cells and Insulin

gina_evans0312
Quiz by , created over 5 years ago

Year 2 (Insulin & Glucagon) Quiz on Beta Cells and Insulin, created by gina_evans0312 on 03/04/2014.

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gina_evans0312
Created by gina_evans0312 over 5 years ago
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Question 1

Question
Pre-Proinsulin contains an R.E.R signal that moves it to the golgi
Answer
  • True
  • False

Question 2

Question
What is the role of the C-peptide part of the insulin chain
Answer
  • Formation of disulphide bonds between the alpha and beta chains
  • Formation of Fe-S bonds between the alpha and beta chains
  • Formation of peptide bonds between the alpha and beta chains

Question 3

Question
Pro-insulin is made of the alpha & beta chains and the c peptide
Answer
  • True
  • False

Question 4

Question
Which of the following cleave the c-peptide from the proinsulin?
Answer
  • Endopeptidase
  • Enteropeptidase
  • Carboxypeptidase

Question 5

Question
What form does newly made insulin take?
Answer
  • Granules
  • Crystals
  • Rods

Question 6

Question
The cleaved C-peptide is released along with the insulin
Answer
  • True
  • False

Question 7

Question
Why do Mannoheptulases inhibit insulin release?
Answer
  • The insulin secretion system relies on the phosphorylation of glucose, which MHLs inhibit
  • MHLs block excretory channels
  • MHLs prevent the movement of insulin to the RER

Question 8

Question
Optimum insulin secretion occurs at 8mM
Answer
  • True
  • False

Question 9

Question
Why is optimal secretion of insulin at 8mM
Answer
  • GLUT 2 & glucokinase have Kms of 8
  • Not gonna put anything else
  • Because reasons

Question 10

Question
Insulin secretion relies on ATP dependent K+ channels
Answer
  • True
  • False

Question 11

Question
K+ buildup causes Ca2+ influx and insulin secretion
Answer
  • True
  • False

Question 12

Question
Which drugs block K+ channels and mimic high glucose?
Answer
  • Sulpynoylurea
  • Sulphinomides
  • Sulphinomics

Question 13

Question
Diazoxide causes insulin secretion by keeping channels open
Answer
  • True
  • False

Question 14

Question
High doses of adrenaline stimulates insulin secretion through _ receptors
Answer
  • Alpha 1
  • Alpha 2
  • Beta 1
  • Beta 2

Question 15

Question
Low concs of adrenaline inhibit insulin secretion through Beta receptors
Answer
  • True
  • False

Question 16

Question
Insulin is catabolic
Answer
  • True
  • False

Question 17

Question
Insulin stimulates _ activity in order to reduce cAMP levels
Answer
  • Phosphodiesterases
  • Adenylate cyclase

Question 18

Question
Which of the following metabolites are reduced?
Answer
  • Fatty Acyl CoA
  • Acetyl CoA
  • Malonyl CoA
  • Palmitite

Question 19

Question
Inc. Phosphorylation of tyrosine kinase by insulin causes what?
Answer
  • Inc tyrosine kinase activity
  • Inc phosphatase activity
  • Inc Adenylate cyclase activity