Glycogen Phosphorylase Control In The Liver

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Flashcards by gina_evans0312, updated more than 1 year ago
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Year 2 (Insulin & Glucagon) Flashcards on Glycogen Phosphorylase Control In The Liver, created by gina_evans0312 on 11/03/2014.

Resource summary

Question Answer
Low Glucose- Protein Phosphatase A is bound to Glycogen phosphorylase- affinity is high
Glucose Low- Glyocgen Phophorylase is Phosphorylated (hidden and cannot be removed)
Glucose Rises- Glucose Stabilises Tense form of protein Glycogen phosphorylase A
Glucose Rises- Glycogen Phosphorylase is Dephosphorylated by protein phosphatase 1
Glucose High- Protein Phosphatase 1 Glycogen synthase is dephosphorylated, and glycogen synthase continues
Glucose High- Glycogen Phosphorylase Glucose binds to it, causing its tense, inactive form
Why only in the liver? GLUT2 transporters
GLUT2 Glucose Affinity Low, so it's only active when blood glucose is high and its a good time to store it
Why Glucokinase? High glucose Km, so it only functions when blood glucose levels are high
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