Quiz
Anti-Diabetic Drugs Quiz
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Questions in this quiz (85)
1Which of the following drugs are the only medications approved for the use in the treatment of Type 1 DM?
- APramlintide (Symlin)
- BMiglitol (Gylset)
- CInsulin
- DPioglitazone (Actos)
2Increntin hormones like GLP-1 and GIP stimulate insulin secretion in response to meals
- ATrue
- BFalse
3Specify how each of the following specified areas contribute to the pathophysiology of Type 2 DM
- Adecreased glucose uptake
- Bdecreased incretin effect
- Cincreased lipolysis
- Ddecreased insulin secretion (beta cells)
- Edecreased glucose uptake
- Fincreased production of glucose
- Gneurotransmitter dysfunction
- Hincreased glucagon secretion
- Iincreased lipolysis
- Jdecreased glucose uptake
- Kincrease production of glucose
- Lincrease glucose reabsorption
- Mneurotransmitter dysfunction
- Nincreased glucose reabsorption
- Odecreased incretin effect
- Pincrease glucagon secretion
- Qneurotransmitter dysfunction
- Rincreased lipolysis
- Sdecrease glucose uptake
- Tincreased production of glucose
- Uincreased glucagon secretion (alpha cell
- Vdecreased glucose uptake
- Wincreased glucose reabsorption
- Xincreased lipolysis
- Ydecreased glucose uptake
- Zincreased production of glucose
- AAdecreased incretin effect
- ABincreased glucagon secretion (alpha)
- ACdecreased insulin secretion (beta cells)
- ADincreased glucagon secretion (alpha cell
- AEdecreased incretin effect
- AFincreased lipolysis
4Pramlintide (Symlin) belongs to what drug class?
- Aalpha-glucosidase inhibitors
- Bamylinomimetics
- CMegltinides
- DSulfonylureas
5What type of efficacy does the following anti-diabetic drugs have?
Metformin, Sulfonyureas, TZDs, GLP-1- ALow efficacy (< 0.5 decrease in A1C)
- BIntermediate efficacy (~0.5-1 % decrease in A1C)
- CHigh efficacy ( ~1-2% decrease in A1C)
6What type of efficacy do the following drugs have?
SGLT2, DPP-IV, Alpha-glucosidase inhibitors- AHigh efficacy (~1-2% decrease in A1C)
- BIntermediate efficacy (~0.5-1% decrease in A1C)
- CLow efficacy (< 0.5% decrease in A1C)
7Of the following anti-diabetic drugs, which have the lowest efficacy in regards to the lowering of the A1C?
- AColesvelam
- BMetformin
- CInsulins
- DBromocriptine
8[blank_start]Pramlintide (Symlin)[blank_end] has a BBW for severe HYPOglycemia
- APramlintide
9Which of the following are contraindications for Pramlintide (Symlin)?
- Agastroparesis
- BHYPOglycemic unawareness
- Cpoor compliance with drug insulin regimens
- Dpediatric patients
- Einflammatory bowel disease
- Fcolonic ulceration
10If taking anti-diabetic drug [blank_start]Pramlintide (Symlin)[blank_end], the meal time insulin must reduced by 50%.
- APramlintide
11Pramlintide (Symlin) must be injected immediately prior to each major meal.
- ATrue
- BFalse
12Miglitol (Glyset) and Acarbose (Precose) belong to what anti-diabetic drug class?
- AAmylinomimetics
- Balpha-glucosidase inhibitors
- CBiguanides
- DTZD's
13What is the MOA for the alpha-glucosidase inhibitors?
- Aactivation of amylin
- Bactivates the nuclear transcription factor PPAR-gamma
- Cinhibits intestinal alpha glucosidase
- Dactivates GLP-1 receptors
14The [blank_start]alpha-glucosidase[blank_end] drug class slows intestinal carbohydrate digestion/absorption.
- Aalpha-glucosidase
- Bsecretagogues
- CTZDs
- DBiguanides
15Alpha-glucosidase drugs must be taken with the 1st bite of each meal
- ATrue
- BFalse
16Which of the following are adverse drug reactions for alpha-glucosidase class?
- AGI disturbances
- Bflatulence
- Cheadache
- Delevation in hepatic enzymes
17Contrainidcations for the [blank_start]alpha-glucosidase inhibitors[blank_end] include inflammatory bowel disease, colonic ulceration, intestinal obstruction, malabsorption, and CrCL < 25 mL/min
- Aalpha-glucosidase inhibitors
- Bamylinomimetics
- CDPP-IV
- DMeglitinides
18Hypoglycemia must be treated with what when taking an alpha glucosidase inhibitor.
- Acomplex carbs
- Binsulins
- Csimple carbohydrates
19Which of the following are the mechanisms of action for the biguanides class?
- Adecrease glucose production from the liver
- Bcloses a K(ATP) channels on beta-cell plasma membranes
- Cincreases insulin sensitivity in muscle
- Ddecrease carbohydrate uptake in gut
20Which of the following are the mechanisms of action for the biguanides class?
- Acloses K(ATP) channels on beta-cell plasma membranes
- Bdecreases glucose production form liver
- Cincreases insulin sensitivity in muscle
- Ddecreases uptake in gut
21What is the physiological action of the Biguanides class?
- Aincreases insulin secretions
- Bdecreases hepatic glucose production
- Cincreases incretin levels
- Ddecreases glucagon secretion
22The maximum effective does for Metformin (Glucophage) is [blank_start]2000[blank_end] mg/day
- A2000
- B1500
- C1000
- D2250
23Metformin (Glucophage) has a BBW for lactic acidosis
- ATrue
- BFalse
24Iodinated contrast media, unstable HF, eGFR < 30 mL/min, hepatic dysfunction, dehydration, pre-renal azotemia, hypoxic states, CKD, and acidosis are all contraindications for [blank_start]Metformin (Glucophage)[blank_end]
- AMetformin
25[blank_start]Metformin (Glucophage)[blank_end] is the first line therapy for T2DM.
- AMetformin
26Starting metformin in patients with an eGFR between 45-50 mL/min/1.73m is not recommended.
- ATrue
- BFalse
27The following drugs belong to what class?
Glyburide (Micronase)
Glyburide (Micronized) - (Glynase)
Glipizide (Glucotrol)
Glimepiride (Amaryl)- ABiguanides
- BDDP-IV
- CTZD's
- DSulfonylureas
28Closure of the K(ATP) channels on beta-cell plasma membranes is the MOA for what class(es) of drugs?
- ASulfonylureas
- BTZDs
- CBile Acid sequestrants
- DMeglitinides
29Which of the following are ADR's for the sulfonylurea class?
- AHYPOglycemia
- BSIADH
- Cphotosensitivity
- DGI disturbances
- EB12 deficiency
- Finduced ovulation in PCOS
- Gsulfa-allergy
30[blank_start]Sulfonrylureas[blank_end] should NOT be used in elderly patients or patients with hepatic impairment
- ASulfonylureas
31Which of the sulfonylureas can be used during pregnancy?
- AGlyburide (Micronase)
- BGlipizide (Glucotrol)
- CGlimepiride (Amaryl)
32For the sulfonylurea class, 1/2 of the max dose is equal to 80% drug effectiveness
- ATrue
- BFalse
33Sulfonylureas can be used in combination with insulin
- ATrue
- BFalse
34Glynase can be interchanged with the drug Mirconase.
- ATrue
- BFalse
35Of the sulfonylureas, [blank_start]Glipizide (Glucotrol)[blank_end] should be utilized in patients with renal impariement.
- AGlipizide
36Which of the following drugs are Meglitinides?
- ANateglinide (Starlix)
- BPioglitazone (Actos)
- CRepaglinide (Prandin)
- DRosiglitazone (Avandia)
37Which of the following are ADR's for the Meglitinides?
- Aincreased fluid retention
- Bbladder cancer
- CHYPOglycemia
- Ddizziness
- EGI disturbances
38[blank_start]Meglitinides[blank_end] can be antidiabetic drug that can be reccommended for patients who are meal skippers.
- AMeglitinides
39Repaglinide (Prandin) is contraindicated with Gemfibrozil
- ATrue
- BFalse
40Which drugs listed below belong the Thiazolidinediones (TZDs) class?
- ASitagliptin (Januvia)
- BLinagliptin (Tradjenta)
- CPioglitazone (Actos)
- DRosiglitazone (Avandia)
41What is the MOA for the Thiazolidinediones class?
- Aclosure of the K(ATP) channels on the beta-cell membranes
- Bactivates dopaminergic receptors
- Cactivates GLP-1 receptors
- Dactivates the nuclear transcription factor PPAR-gamma
42What is the physiological action for the TZD class?
- Aincreases insulin secretion
- Bincreases insulin sensitivity in the skeletal muscle, adipocytes, and liver
- Cdecreases hepatic glucose production
43[blank_start]TZDs[blank_end] have a BBW warning for heart failure
- ATZDs
- BMeglitinides
- CDPP-IV inhibitors
- DBile Acid Sequestrants
44Select the ADRs of the TZD class
- Aincrease in fluid retention
- Bdizziness
- Cperipheral edema
- Dhepatotoxicity
- Ebladder cancer
- Ffractures
- Gmacular edema
45Which patient should not take TZDs for their diabetes?
- APatients with Class III or IV heart failure
- BPatient with Type 1 DM
- CPatients with the risk of bone fracture
46Of the TZD drugs, which has an improved lipid profile?
- APioglitazone (Actos)
- BRosiglitazone (Avandia)
47TZDs can be used in combination with Metformin
- ATrue
- BFalse
48[blank_start]Colesevelam (Welchol)[blank_end] is a bile acid sequestrant
- AColesevelam
49Binds bile acids in intestinal tract, increasing hepatic bile acid production and activates the farnesoid X receptor (FXR) in the liver is the MOA for what drug class?
- ADopamine agonist
- BBile acid sequestrant
- CDPP-IV inhibitors
- DBiguanides
50Indicate the physiological actions of the bile acid sequestrant class?
- ADecreases hepatic glucose production
- Bincreases incretin levels
- Cincreases insulin sensitivity
- Dactivates GLP-1 receptors
51Which of the following are ADR's for bile acid sequestrant?
- Aconstipation
- Bincreases in TG
- Cpancreatitis
- Ddecreases absorption of other medications
- EGI upset
- Ffatigue
52Bowel obstructions, TG > 500 mg/dL, and history of hypertriglyceridemia-induced pancreatitis are contraindications for ....
- ADopamine agonist
- BBile acid sequestrant
- CDPP-IV
- DSGLT-2
53Colesevelam (Welchol) can be approved for monotherapy
- ATrue
- BFalse
54Bromocriptine (Cycloset) belongs to what anti-diabetic drug class?
- ABile acid sequestrant
- BSGLT-2
- CDopamine agonist
- DGLP-1
55What is the MOA for Bromocriptine (Cycloset)?
- Ainhibits DPP-IV activity
- Bactivates GLP-1 receptors
- Cinhibits SGLT-2 in the proximal tubule
- Dactivates dopaminergic receptors
56What are the physiological actions for the Dopamine agonist class?
- Amodulates HYPOthalamic regulation of metabolism
- Bdecrease hepatic glucose production
- Cincreased incretin levels
- Dincreased insulin sensitivity
57Postural hypotension, headache, fatigue, hallucinations, psychotic disorder, pleural effusion, pulmonary fibrosis, and GI ulcers are the ADR's for what drug?
- AColesevelam (Welchol)
- BBromocriptine (Cycloset)
- CSitagliptin (Januvia)
- DLiraglutide (Victoza)
58Which of the following are contraindications for the Bromocriptine (Cycloset)?
- AHypersensitivity to ergot derivation or dopamine
- Blactation
- Csyncopal migraines
- Dsevere renal impairment
59Bromocriptine (Cycloset) is not approved for monotherapy.
- ATrue
- BFalse
60What drug class do the following drugs belong to?
Sitagliptin (Januvia)
Saxagliptin (Onglyza)
Linagliptin (Tradjenta)
Alogliptin (Nesina)- ADPP-IV
- BSGLT2 inhibitors
- CDopamine agonist
- DGLP-1 agonist
61Inhibits DPP-IV activity, increasing postprandial active incretin concentrations is the MOA for what drug class?
- AGLP-1
- BTZDs
- CBiguanides
- DDPP-IV inhibitors
62What are the physiological actions for the DPP-IV inhibitors? (select all that apply)
- Aincreases insulin secretion (glucose-dependent)
- Bincrease renal excretion of glucose
- Cdecrease glucagon secretion (glucose-dependent)
- Dslows gastric emptying
63Of the DPP-IV inhibitors, which one does not need to be adjusted in renal and hepatic impairment?
- AAlogliptin (Nesina)
- BLinagliptin (Tradjenta)
- CSaxagliptin (Onglyza)
- DSitagliptin (Januvia)
64ADR's for DPP-IV's include which of the following
- Aupper respiratory infection
- Bperipheral edema
- Cdecreased BP
- Dpancreatitis
- ESJS
- Frhabdomyolysis
65FDA warns that [blank_start]DPP-4 inhibitors[blank_end] may cause severe joint pain that can be severe or diabiling
- ADPP-4 inhibitors
- BSGLT-2
- CGLP-1 inhibitors
- DTZDs
66Which of the DPP-IV inhibitors can cause heart failure?
- ASitagliptin (Januvia)
- BSaxagliptin (Onglyza)
- CLinagliptin (Tradjenta)
- DAlogliptin (Nesina)
67The following drugs belong to what drug class?
Exenatide (Byetta)
Liraglutide (Victoza)
Abiglutide (Tanzeum)
Dulagultide (Trulicity)- AGLP-1 agonist
- BTZDs
- CDPP-IV
- DSGLT-2
68Select the physiological actions of the GLP-1 class
- Aincreases insulin secretion (glucose-dependent)
- Bdecreases glucagon (glucose-dependent)
- Cslows gastric emptying
- Dincreases satiety
69Of the GLP-1 agonist, which one can not be used if the CrCL is < 30 mL/min?
- AExenatide (Byetta)
- BLiraglutide (Victoza)
- CAbiglutide (Tanzeum)
- DDulaglutide (Trulicity)
70Of the GLP-1 inhibitors, which ones have a BBW warning for thyroid carcinoma?
- AExenatide (Byetta)
- BLiraglutide (Victoza)
- CAbiglutide (Tanzeum)
- DDulaglutide (Trulicity)
71History of pancreatitis, gastroparesis or GI disease, and caution in renal impairment are all contrainidcations for the [blank_start]GLP-1 agontist[blank_end]
- AGLP-1 agonist
- BDPP-IV
- CTZDs
- DSGLT-2
72The following drugs belong to what drug class?
Canagliflozin (Invokana)
Dapagliflozin (Farxiga)
Empagliflozin (Jardiance)- ASGLT-2 inhibitors
- BDPP-IV
- CBiguanides
- DMeglitinides
73Which of the following are ADR's for the SGLT-2 inhibitor drug class?
- Afemale & male genital mycotic infections
- Bincreased urination
- Cincreased BP
- Ddecreased BP
- Epancreatitis
- Fhypovolemia
- Ghyperkalemia
74Hypovolemia must be corrected prior to starting a SGLT-2 inhibitor
- ATrue
- BFalse
75Increased risk of bladder cancer and bone fracture with [blank_start]Dapagliflozin (Farxiga)[blank_end]
- ADapagliflozin (Farxiga)
- BCanagliflozin (Invokana)
- CEmpagliflozin (Jardiance)
76[blank_start]Empagliflozin (Jardiance)[blank_end] is assocaited with an increase in CV events
- AEmpagliflozin (Jardiance)
- BCanagliflozin (Invokana)
- CDapagliflozin (Farxiga)
77[blank_start]Canagliflozin (Invokana)[blank_end] may be associated with an increase in lower extremity amputations
- ACanagliflozin (Invokana)
- BDapagliflozin (Farxiga)
- CEmpagliflozin (Jardiance)
78Which drug classes target fasting BG only!
- ABiguanides
- BTZDs
- CSGLT-2
- DAmylinomimetics
79Which drug classes targets post-prandial blood glucose only!
- ABiguanides
- BSulfonylureas
- CAmylinomimetics
- Dalpha-glucosidase inhibitors
- Edopamine agonist
- FDPP-4 inhibitors
- Gmeglitinides
80What drug classes target BOTH fasting and postprandial BG levels?
- ASulfonylureas
- BTZDs
- CSGLT-2 inhibitors
- DBile acid sequestrants
81GLP-1 agonist, Metformin, SGLT-2, Amylinmimetics all cause [blank_start]weight loss[blank_end]
- Aweight loss
- Bweight gain
- Cweight neutral
82Metformin, alpha-glucosidase inhibitors, DPP-IV inhibitors all cause [blank_start]weight gain[blank_end]
- Aweight gain
- Bweight loss
- Cweight neutral
83Suflonylureas, Meglitinides, insulins, and TZDs all cause [blank_start]weight loss[blank_end]
- Aweight loss
- Bweight gain
- Cweight neutral
84Which drug classes are high cost agents?
- AGLP-1
- BSGLT-2
- CDPP-IV
- DInsulins
- EMetformin
- FSulfonylureas
- GTZDs
85Which drugs classes are low cost agents?
- AMetformin
- BSulfonylureas
- CDPP-IV
- DTZDs
- EGLP-1
- FSGLT-2
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- NAPLEX Pharmacy (Endo) Quiz on Anti-Diabetic Drugs Quiz , created by Mark W. on 12/12/2016.
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- Mark W.
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- English
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