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Thyroid disease

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undergraduate second year Clinical Biochemisty Quiz on Thyroid disease, created by Idont Evencare on 11/01/2017.
Idont Evencare
Quiz by Idont Evencare, updated more than 1 year ago
Idont Evencare
Created by Idont Evencare about 9 years ago
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Resource summary

Question 1

Question
Raised TSH (thyroid stimulating hormone) indicates
Answer
  • primary hypothyroidism
  • primary hyperthyroidism
  • secondary hypothyroidism due to pituitary failure

Question 2

Question
Low TF4 (free T4) indicates
Answer
  • primary hypothyroidism
  • primary hyperthyroidism
  • secondary hypothyroidsim

Question 3

Question
What tests are performed as a first line screen for thyroid disease?
Answer
  • FT4 (free T4)
  • TSH (thyroid stimulating hormone)
  • TSH and FT4
  • TRH (thyrotropin releasing hormone)
  • TRH and TSH
  • TRH, FT4 and TSH

Question 4

Question
TSH (thyroid stimulating hormone) is used to screen for secondary hypothyroidism.
Answer
  • True
  • False

Question 5

Question
What test would you use for a patient with normal FT4 (free T4) but persistently low TSH (thyroid stimulating hormone)?
Answer
  • T3 (Triiodothyronine)
  • Thyroglobulin
  • Thyroid peroxidase bodies
  • TRH test (thyrotropin-releasing hormone)

Question 6

Question
T3 (Triiodothyronine) is used to detect
Answer
  • early hyperthyroidsm
  • early hypothyroidism
  • T3 toxicosis
  • tumour recurrence
  • Hashimoto’s thyroiditis
  • Grave’s disease

Question 7

Question
What test can be performed if the interpretation of TFT (thyroid function tests) is difficult due to presence of drugs such as amiodarone?
Answer
  • TSH (thryoid stimulating hormone)
  • T3 (triiodothyronine)
  • FT4 (free T4)
  • TPO (Thyroid peroxidase antibodies)

Question 8

Question
Which of the following statement about thyroglobulin are incorrect?
Answer
  • Thyroglobulin is widely used in diagnosing thyroid cancer
  • Thyroglobulin is useful in detecting tumour recurrence following thyroidectomy
  • Endogenous antibodies limit the use of thyroglobulin
  • It is made by the follicular cells of the thyroid gland

Question 9

Question
Steep elevation in TPO (thyroid peroxidase antibodies) can be found in patients with
Answer
  • Primary hypothyroidism
  • Grave’s disease
  • Secondary hypothyroidism
  • Hashimoto’s thyroiditis
  • Thyroiditis

Question 10

Question
Which of the following statements about TRH test (thyrotropin releasing hormone) is/are correct?
Answer
  • In primary hyperthyroidism there is an exaggerate rise
  • In primary hypothyroidism there is no rise
  • In primary hyperthyroidism there is no rise
  • In primary hypothyroidism there is an exaggerate rise

Question 11

Question
What procedures are used in clinical evaluation of thyroid function?
Answer
  • Presence of nodules
  • Changes in size/texture of gland
  • Thyroid MRI
  • Thyroid biopsy
  • Thyroid imaging using ultrasound
  • TPO (Thyroid peroxidase antibodies)
  • Thyroid scintiscanning-99mTc-pertechnetate

Question 12

Question
How is Thyroid scintiscanning-99mTc-pertechnetate carried out?
Answer
  • the gland imaged every 4-6 h using a gamma camera
  • the gland imaged every 24h using a gamma camera
  • the gland imaged every 4-6 h using a UV camera
  • the gland imaged every 24 h using a UV camera

Question 13

Question
What does increased uptake in Thyroid scintiscanning-99mTc-pertechnetate test indicate?
Answer
  • Grave’s disease
  • Hypothyroidism
  • toxic nodular goitre
  • anti-thyroid drug administration
  • thyroxine administration
  • iodine deficiency
  • recovery from sub-acute thyroiditis
  • subacute thyroiditis
  • thyroid ablation

Question 14

Question
What does decreased uptake in Thyroid scintiscanning-99mTc-pertechnetate test indicate?
Answer
  • thyroid ablation
  • subacute thyroiditis
  • iodine deficiency
  • toxic nodular goitre
  • hypothyroidism
  • Grave’s disease
  • thyroxine administration
  • anti-thyroid drug administration
  • recovery from sub-acute thyroiditis

Question 15

Question
What condition shows raised TSH (thyroid stimulating hormone) and decreased FT4 (free T4)?
Answer
  • Primary Hypothyroidism / under-replacement
  • Primary Hyperthyroidism / over-replacement
  • Secondary hypothyroidism

Question 16

Question
What condition shows mildly raised TSH with normal T4
Answer
  • Subclinical hypothyroidism
  • Primary hypothyroidism
  • Secondary hyperthyroidism
  • Primary hyperthyroidism
  • Subclinical hyperthyroidism

Question 17

Question
Abnormal levels of T4/T3 can be observed even in non-thyroidal illnesses.
Answer
  • True
  • False

Question 18

Question
What effect does Thyroxine have?
Answer
  • T4 levels increase rapidly, TSH declines slowly
  • T4 levels increase rapidly, TSH declines rapidly
  • T4 levels increase slowly, TSH declines slowly
  • T4 levels decrease rapidly, TSH levels increase rapidly
  • T4 levels decrease slowly, TSH levels increase rapidly

Question 19

Question
Which statement about Amiodarone is incorrect?
Answer
  • May cause hypothyroidism
  • May cause hyperthyroidism
  • May cause raised T4
  • May cause reduced T4

Question 20

Question
Which medication may cause hypothyroidism by inhibiting secretion of T4 and T3
Answer
  • Amiodarone
  • Lithium
  • Anticonvulsants
  • Antipsychotics

Question 21

Question
Which of the following drugs is NOT used to treat thyroid disease?
Answer
  • Antipsychotics
  • Lithium
  • Armour Thyroid
  • Immunosuppressants

Question 22

Question
Which of the following are the symptoms of hypothyroidsm?
Answer
  • weight loss
  • weight gain
  • menorrhagia
  • oligomenorrhoea
  • lethargy
  • sweating

Question 23

Question
Which of the following are the symptoms of hyperthyroidism?
Answer
  • sweating
  • weight loss
  • weight gain
  • palpitations
  • hoarseness
  • menorrhagia
  • diarrhoea
  • coarse skin

Question 24

Question
What are the clinical features of hypothyroidism?
Answer
  • Hypothermia
  • Bradycardia
  • Reflex relaxation delay
  • Sinus tachycardia
  • Anaemia
  • Eyelid retraction/lid lag
  • Myxoedema coma
  • Proximal myopathy

Question 25

Question
What are the clinical features of hyperthyroidism?
Answer
  • Raised serum cholesterol
  • Eyelid retraction
  • Myxoedema coma
  • Tremor
  • Proximal myopathy
  • Anaemia

Question 26

Question
What are the causes of hypothyroidism?
Answer
  • Atrophic
  • Iodine deficiency
  • Graves Disease
  • Iatrogenic
  • Toxic Multinodular Goitre
  • Congenital
  • Solitary toxic adenoma
  • Autoimmune
  • Dyshormonogenetic

Question 27

Question
What are the causes of hyperthyroidism?
Answer
  • Iodine deficiency
  • Toxic Multinodular Goitre
  • Congenital
  • Iodine containing drugs
  • Iatrogenic
  • Ectopic thyroid tissue
  • Dyshormonogenetic
  • Solitary toxic adenoma

Question 28

Question
Why does T4 therapy not work during acute illness?
Answer
  • reduced conversion of T4 to T3
  • rised TSH interferes with T4
  • reduced conversion of T4 to TRH
  • rised TSH interferes with TRH

Question 29

Question
Which of the following statements about age influence of age on TFTs are correct?
Answer
  • 24h after birth TSH rises transiently
  • 24h after birth TSH drops transiently
  • FT4 levels rise at old age
  • FT4 levels drop at old age

Question 30

Question
Which of the following statements about pregnancy influences on TFTs are correct?
Answer
  • TRH can cross placenta
  • TSH can cross placenta
  • Iodide and anti-thyroid drugs can cross the placenta
  • Iodide and anti-thyroid drugs cannot cross the placenta
  • Oestrogen causes an increase in thyroid binding globulin
  • Oestrogen causes an decrease in thyroid binding globulin

Question 31

Question
T4 secretion can be inhibited by
Answer
  • lithium
  • dopamine
  • iodide
  • glucocorticoids
  • amiodarone

Question 32

Question
What is thyroiditis?
Answer
  • Inflammation of thyroid gland
  • Thyroid malignancy
  • Autoimmune disease

Question 33

Question
Thyroiditis involves initial hyperthyroidism and eventual hypothyroidism.
Answer
  • True
  • False

Question 34

Question
How can thyroid cancer be treated
Answer
  • removal of nodule
  • removal of thyroid
  • irradiation with I isotope
  • iodine drug administration
  • supressive doses of thyroxine
  • T4 administration
  • Lithium administration

Question 35

Question
Who is screened for thyroid disease?
Answer
  • Children with Type I diabetes
  • Patients following neck surgery
  • Everyone
  • No one
  • Children with Down´s disease
  • People with sickle cell anaemia
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