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sex and inheritance
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- 1SRY(Sex-determining region Y) is gene on the Y chromosome. This intronless gene encodes a transcription factor that initiates male sex determination. allows bipotential primordial gonad cells to differentiate and proliferate
- 2although SRYis the trigger to sexual differentiation, other genes are also involved, these include1. FTZ-F1 (SF-1) 2. SOX9
- 3Is Sox9: an SRY-target gene? - EVIDENCE1. Sox9 expression is strongly upregulated soon after the expression of SRY begins, whereas it is downregulated in the ovary
2. SRY-positive cells exclusively become SOX9-positive Sertoli cells - 4SRY gene encodes a gene that affectstesticular differentiation.
- 5Following Sry activation and testes developmentmale determining signal is sent out via two factors, anti-Mullerian hormone (from sertoli cells) and testosterone. these cause the major differences between males and females.
- 6All other differences between sexes are secondary and due to‘turning on’ of genes encoding hormones or factors produced by the gonads.
- 7In the absence of a signal (testis determining factor)ovaries are formed.
- 8The primary event of sex determination is thedifferentiation of this gonadal tissue into testes rather than ovaries.
Differentiation of gonadal tissue causes a male determining signal to be sent out via anti-Mullerian hormone and testosterone
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- Genetics Karteikarten am sex and inheritance, erstellt von lumen7 am 12/05/2013.
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