Glucose (6c)

Glucose (6c)

1. 50% of calories from carbs

2. major sugar in body

3. utilization

   • storage
     • sucrose
     • glycogen
     • starch
   • synth of stx polymers
     • extracellular matrix
   • Metabolism
     • glucose 6-P
       • oxidation
         • glycolysis
           • Anaerobic
           • cytosol
           • I: preparative (investment)
             • fructose 6-P
               • fructose 1,6-bis-P
                 • II: ATP generating (payoff)
                   • 2 triose phosphates (3C) PGAL
                     • 2 NADH
                     • 4 ATP
                     • glyceraldehyde 3-P
                       • phosphoenol pyruvate (PEP)
                         • 2 pyruvate (3C)
                           • aerobic
                             • 2 GTPs, 8 NADH, 2 FADH2
                             • 2 acetyl-CoA
                               • TCA Cycle
                                 • Electron transport chain
                                   • 10 NADH, 2 FADH2
                                   • 28-30 ATPs + 10 NAD+ 2 FAD+
                                 • mitochondrion
                             • NAD+ regenerated thru ETC
                           • anaerobic
                             • 2 lactate
                               • lactate dehydrogenase
                                 • regenerates NAD+
                             • 2 etoh + 2co2
                           • pyruvate kinase
                           • ATP->ADP
                       • oxidized
                       • phosphorylated
                 • phosphofructokinase-1 PFK-1
                 • ATP->ADP
                 • allosterically reg
                   • inhibited by ATP
                   • activated by AMP
               • phosphoglucose isomerase
           • 10 ez and 3 reg steps
         • pentose phosphate pathway
       • -∆G irreversible
       • hexokinase
       • glucokinase (liver)
       • ATP-> ADP
       • glycogen synth