Septic Shock

Septic Shock

1. Pathogenesis

   • Invading Microorganisms
     • Release of proinflammatory cytokines such as Tumor Necorsis Factor:, Interleukin-1 and other proinflammatory cytokines

2. Diagnosis

3. Assessment

   • Clinical Presentation
     • Cardiovascular
       • Increased or decreased temperature
       • Biventricular dilation: decreased ejection fraction
     • Pulmonary
       • Hyperventilation
       • Respiratory alkalosis leading to respiratory acidosis
       • Hypoxemia
       • Respiratory Failure
       • ARDS
       • Pulmonary Hypertension
       • Crackles
     • Renal
       • Decreasing urine output leading to oliguria
     • Skini
       • Warm and flushed (early sign)
       • Cool & mottled (Late sign)
     • Neuro
       • Altered mental state
       • Agitation
       • Coma (late stage)
     • Gastrointestinal
       • GI bleeding
       • Paralytic Ileus
     • Other Diagnostic Findings
       • Increased or decreased White Blood Cell count
       • Decreased platelets
       • Increased lactate
       • Increased glucose
       • Increased urine specific gravity
       • Decreased Urine Sodium
       • Positive Blood Cultures

4. Treatment

5. Complications