C3

Beschreibung

Complement pathways
Amaal Salhieh
Mindmap von Amaal Salhieh, aktualisiert more than 1 year ago
Amaal Salhieh
Erstellt von Amaal Salhieh vor etwa 8 Jahre
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Zusammenfassung der Ressource

C3
  1. iC3
    1. D Cleaves B into Ba and Bb
      1. Ba is released
        1. Bb + iC3 = iC3b
          1. iC3b
            1. cleaves C3 into C3a and C3b
              1. C3b attaches to pathogen
                1. D cleaves B into Ba and Bb
                  1. C3b + Bb = C3bBb
                    1. alternative C3 convertase
                      1. alternative C5 convertase
                        1. C3b2Bb
                          1. Cleaves C5 into C5a and C5b
                            1. C5b initiates membrane-attack complex
                              1. C6, C7, C8 bind
                                1. C9 polymerizes
                              2. C5a
                                1. Analphylatoxins
                            2. + C3b
                          2. Ba is released
                          3. B
                          4. C3a
                            1. classical C3 convertase
                              1. C4bC2a
                                1. C2a
                                  1. C2
                                      1. C2b
                                    1. C4b
                                      1. C4
                                        1. cleaves
                                          1. MASP2
                                            1. Lectin Pathway
                                            2. C1s
                                              1. CRP
                                                1. binds to C1q
                                                  1. C1r cuts itself
                                                    1. C1r cuts other C1r
                                                      1. <-- C1r cuts both C1s
                                                        1. C1s
                                                    2. Classical Pathway
                                                2. C4a
                                                  1. Anaphylatoxins
                                      2. soluble C3 convertase
                                    2. B
                                    3. Hydrolysis
                                      Zusammenfassung anzeigen Zusammenfassung ausblenden

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