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Glycolysis

Beschreibung

Mindmap am Glycolysis, erstellt von minicheddars am 07/05/2013.
minicheddars
Mindmap von minicheddars, aktualisiert more than 1 year ago
minicheddars
Erstellt von minicheddars vor fast 13 Jahre
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Zusammenfassung der Ressource

Glycolysis
  1. Stage 1
    1. Requires 2 ATP
      1. Traps and destabilises glucose
        1. Forms 2x 3C
      2. Stage 2
        1. Generates 4 ATP
          1. oxidises to pyruvate
          2. Stage 1 Step 1
            1. Trap glucose
              1. Enters cells via facilitated diffusion
                1. Through transporters
                  1. GLUT 3
                    1. Brain, nerve tissue
                      1. Low Km - constant uptake
                      2. GLUT 2
                        1. Liver, Beta cells in pancreas
                          1. High Km - proportional uptake
                          2. GLUT 4
                            1. Muscle and adipocytes
                        2. Phosphorylated
                          1. Negatively charged so cannot diffuse out
                            1. Hexokinase
                              1. induced fit model
                                1. feedback inhibition
                                  1. Effectively irreversible
                              2. Stage 1 Step 2
                                1. Form Fructose 6-Phosphate
                                  1. isomerisation
                                    1. By enzyme phosphoglucose isomerase
                                    2. Stage 1 Step 3
                                      1. phosphorylation
                                        1. Phosphofructokinase
                                          1. sets the pace of glycolysis
                                            1. inhibited by ATP, Citrate and H+ ions
                                              1. Stimulated by AMP, ADP and fruc 2,6 bisphosphate
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