Arthropod infections

Arthropod infections

1. Yersinia Pestis

   • Background
     • Plague
       • Clinical Types
         • Bubonic
           • enlarged lymph node buboes
           • Not easily transmitted
         • Pneumonic
           • Haemorrhagic bronchopneumonia
           • Highly infectious
       • Diagnosis
         • culture buboes
       • Treatment
         • Antibiotic
           • Tetracycline
           • Streptomycin
   • Adhesins
     • Invasin
       • Binds B1 integrin induces zipper uptake
     • YadA adhesin
       • Binds collagen & mucus
   • Effectors
     • 29 Ysc proteins
       • type III injectosome
     • 12 Yop proteins
       • Yop H
         • Dephoshorylates FAK and SKAP-HOM
           • Inteferes with signal transduction
         • Blocks macrophage recruitment
       • Yop E
       • Yop T
         • activate Rho proteins
           • depolymerises actin
             • cell rounding
       • Yop P/J
         • Blocks apoptosis and block inflammatory signalling
           • Block Erk Map kinase pathway
           • Block lymphocyte prolif.
       • Pass through injectosome

2. Borrelia Burgdorferi

   • Lyme disease
     • Symptoms
       • Stages 1-3
         • 1.acute phase
           • Ring and rash
         • 2. weeks - mnths
           • Neuritis & arthritis
         • 3. Yrs
           • demyelination
     • Diagnosis
       • Culture
       • PCR
       • Serological testing
   • Genome
     • Rapid lipoprotein evolution
       • Immune evasion
     • Outer surface proteins
       • Osp
         • OspA
         • OspC
       • Antigenically variable
         • Changes in environment
           • Temp/Ph/etc
   • Treatment
     • Penicillin/tetracycline