Pip Barton
Mind Map by , created over 6 years ago

Infection Mind Map on STI's, created by Pip Barton on 05/08/2013.

Pip Barton
Created by Pip Barton over 6 years ago
Clostridium Difficile
Kirsty Jayne Buckley
Kit Sinclair
Infection and Inflammation
Biology -B2
Sian Griffiths
Romeo & Juliet Quotes
Lucy Hodgson
Biology - B1 - AQA - GCSE - Keeping Healthy and Defending Against Infection
Josh Anderson
Infectious Disease
Biology 1- Keeping Healthy 2
GCSE AQA Biology - Infection and Response
Eleanor Rose
Infection and response
Brodie McMeowface
1.1 Treponoma Pallidum
1.1.1 Gram negative
1.1.2 Axial filaments
1.2 Infection
1.2.1 1. Primary Chancre 4-6 wks
1.2.2 2. Secondary Fever Rash Liver infection Swollen lymph nodes
1.2.3 3.Tertiary Gumma Soft granular lesion Antibiotic resistance Immune complexes Inflammation Tissue destruction
1.2.4 Congenital Skin lesions Deafness Bone malformation
1.3 Diagnosis
1.3.1 Microscopy
1.3.2 Serological testing
1.4 Treatment
1.4.1 Chemotherapeutic Salvarsan
1.4.2 Antibiotic Penicillin
1.5 Immune evasion
1.5.1 Cell wall Tpr outer membrane protein Phase variation Poly G tract <8 = transcribed >8 = reduced transcription Strand slippage and excision repair Tpr K Antigenic variation
2 Trends
2.1 Age
2.2 Geography
2.3 Sexual orientation
3.1 Chlamydia Trachomatis
3.1.1 Diagnosis PCR Immunoassays
3.1.2 Treatment Doxycyclin
3.1.3 Gram negative
3.1.4 Small genome
3.1.5 Cell wall Cross linked membrane proteins MOMP OmpA
3.2 Symptoms
3.2.1 Males Epididymis inflammation Painful urination, water discharge
3.2.2 Females Cervical inflammation Immune activation Infected cells secrete IL's and GM-CSF Attract immune cells Fibrosis and scarring Painful urination, vaginal discharge PID Fallopian tube adhesions Infertility Ectopic pregnancy AIDs
3.2.3 Infants Chlamydial ophthalmia Chlamydial pneumonia Trachoma Corneal scarring and blindness
3.3 2 stage life cycle
3.3.1 Reticulate body Replication
3.3.2 Elementary body Infection
3.3.3 Cell cycle 1.Attachment OmpA binds heparan sulphate 2.Entry T3SS injects TARP Induces uptake 3.Primary differentiation EB to RB 4.Cell division Rapid multiplication 5.Effector secretion CPAF Degrade host TF's Chronic inflammatory response 6.Secondary differentiation RB to EB (Intermediate form) Chromosomal condensation OMC formation T3SS formation 7.EB release
4.1 Neisseria Gonorrhoeae
4.1.1 Gram negative
4.1.2 diplococcus
4.1.3 Oxidase positive
4.1.4 2nd most common
4.2 Symptoms
4.2.1 Females Vaginal discharge Abdominal pain Burning pee Urinal ouchy pee pee times PID
4.2.2 Males Burning pee pee Pus discharge Epididymitis
4.2.3 Neonates Gonoccocal opthalmia
4.3 Diagnosis
4.3.1 Microscopy
4.3.2 Thayer Martin agar


  • Vancomcin, inhibits gram positive Colistin, inhibits most gram neg Inhibits most others
4.3.3 Immunoassays
4.3.4 PCR
4.4 Treatment
4.4.1 3rd gen cephalosporins
4.5 Virulence mechanisms
4.5.1 Attachment pili Type 4 T2SS Transformation DNA binding Uptake RecA mediated recombination Binds CR3 and CD46
4.5.2 Tight attachments Opa proteins OpaHS Binds heparin sulphate OpaCEA Binds CEACAM Uptake
4.5.3 Change surface proteins Recombination Transformation Gene exchange Antigenic variation Abberant recombination L-pilin PilS and PilE unequal exchange Stuck in periplasm Evades immune system recognition S-pilin Secreted soluble pilin molecular decoy PilE and PilS exchange E for expressed Genetic recombination between homologous segments Phase variation Homopolymeric repeats Tetranucleotide repeats PilC 11-12G = off <11->12 = on CTTCT repeats 3,6,9,12 = on Opa proteins Sialylated lipopolysaccharide Resistant to complement and antibodies Mimics host cell surface

Media attachments