Pip Barton
Mind Map by , created over 6 years ago

Infection Mind Map on STI's, created by Pip Barton on 05/08/2013.

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Pip Barton
Created by Pip Barton over 6 years ago
Clostridium Difficile
Kirsty Jayne Buckley
Pathogens
Kit Sinclair
Infection and Inflammation
hammylovesyou
Biology -B2
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Romeo & Juliet Quotes
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Biology - B1 - AQA - GCSE - Keeping Healthy and Defending Against Infection
Josh Anderson
Infectious Disease
gordonbrad
Biology 1- Keeping Healthy 2
amberbob27
GCSE AQA Biology - Infection and Response
Eleanor Rose
Infection and response
Brodie McMeowface
STI's
1 SYPHILIS
1.1 Treponoma Pallidum
1.1.1 Gram negative
1.1.2 Axial filaments
1.2 Infection
1.2.1 1. Primary
1.2.1.1 Chancre
1.2.1.2 4-6 wks
1.2.2 2. Secondary
1.2.2.1 Fever
1.2.2.2 Rash
1.2.2.3 Liver infection
1.2.2.4 Swollen lymph nodes
1.2.3 3.Tertiary
1.2.3.1 Gumma
1.2.3.1.1 Soft granular lesion
1.2.3.2 Antibiotic resistance
1.2.3.2.1 Immune complexes
1.2.3.2.1.1 Inflammation
1.2.3.2.1.2 Tissue destruction
1.2.4 Congenital
1.2.4.1 Skin lesions
1.2.4.2 Deafness
1.2.4.3 Bone malformation
1.3 Diagnosis
1.3.1 Microscopy
1.3.2 Serological testing
1.4 Treatment
1.4.1 Chemotherapeutic
1.4.1.1 Salvarsan
1.4.2 Antibiotic
1.4.2.1 Penicillin
1.5 Immune evasion
1.5.1 Cell wall
1.5.1.1 Tpr outer membrane protein
1.5.1.1.1 Phase variation
1.5.1.1.1.1 Poly G tract
1.5.1.1.1.1.1 <8 = transcribed
1.5.1.1.1.1.2 >8 = reduced transcription
1.5.1.1.1.1.3 Strand slippage and excision repair
1.5.1.1.2 Tpr K
1.5.1.1.2.1 Antigenic variation
2 Trends
2.1 Age
2.2 Geography
2.3 Sexual orientation
3 CHLAMYDIA
3.1 Chlamydia Trachomatis
3.1.1 Diagnosis
3.1.1.1 PCR
3.1.1.2 Immunoassays
3.1.2 Treatment
3.1.2.1 Doxycyclin
3.1.3 Gram negative
3.1.4 Small genome
3.1.5 Cell wall
3.1.5.1 Cross linked membrane proteins
3.1.5.1.1 MOMP
3.1.5.1.1.1 OmpA
3.2 Symptoms
3.2.1 Males
3.2.1.1 Epididymis inflammation
3.2.1.2 Painful urination, water discharge
3.2.2 Females
3.2.2.1 Cervical inflammation
3.2.2.1.1 Immune activation
3.2.2.1.1.1 Infected cells secrete IL's and GM-CSF
3.2.2.1.1.1.1 Attract immune cells
3.2.2.1.1.1.1.1 Fibrosis and scarring
3.2.2.2 Painful urination, vaginal discharge
3.2.2.3 PID
3.2.2.3.1 Fallopian tube adhesions
3.2.2.3.2 Infertility
3.2.2.3.3 Ectopic pregnancy
3.2.2.3.4 AIDs
3.2.3 Infants
3.2.3.1 Chlamydial ophthalmia
3.2.3.2 Chlamydial pneumonia
3.2.3.3 Trachoma
3.2.3.3.1 Corneal scarring and blindness
3.3 2 stage life cycle
3.3.1 Reticulate body
3.3.1.1 Replication
3.3.2 Elementary body
3.3.2.1 Infection
3.3.3 Cell cycle
3.3.3.1 1.Attachment
3.3.3.1.1 OmpA binds heparan sulphate
3.3.3.2 2.Entry
3.3.3.2.1 T3SS injects TARP
3.3.3.2.1.1 Induces uptake
3.3.3.3 3.Primary differentiation
3.3.3.3.1 EB to RB
3.3.3.4 4.Cell division
3.3.3.4.1 Rapid multiplication
3.3.3.5 5.Effector secretion
3.3.3.5.1 CPAF
3.3.3.5.1.1 Degrade host TF's
3.3.3.5.2 Chronic inflammatory response
3.3.3.6 6.Secondary differentiation
3.3.3.6.1 RB to EB (Intermediate form)
3.3.3.6.2 Chromosomal condensation
3.3.3.6.3 OMC formation
3.3.3.6.4 T3SS formation
3.3.3.7 7.EB release
4 GONORRHOEAE
4.1 Neisseria Gonorrhoeae
4.1.1 Gram negative
4.1.2 diplococcus
4.1.3 Oxidase positive
4.1.4 2nd most common
4.2 Symptoms
4.2.1 Females
4.2.1.1 Vaginal discharge
4.2.1.2 Abdominal pain
4.2.1.3 Burning pee
4.2.1.3.1 Urinal ouchy pee pee times
4.2.1.4 PID
4.2.2 Males
4.2.2.1 Burning pee pee
4.2.2.2 Pus discharge
4.2.2.3 Epididymitis
4.2.3 Neonates
4.2.3.1 Gonoccocal opthalmia
4.3 Diagnosis
4.3.1 Microscopy
4.3.2 Thayer Martin agar

Annotations:

  • Vancomcin, inhibits gram positive Colistin, inhibits most gram neg
4.3.2.1 Inhibits most others
4.3.3 Immunoassays
4.3.4 PCR
4.4 Treatment
4.4.1 3rd gen cephalosporins
4.5 Virulence mechanisms
4.5.1 Attachment pili
4.5.1.1 Type 4
4.5.1.1.1 T2SS
4.5.1.1.1.1 Transformation
4.5.1.1.1.1.1 DNA binding
4.5.1.1.1.1.2 Uptake
4.5.1.1.1.1.3 RecA mediated recombination
4.5.1.1.2 Binds CR3 and CD46
4.5.2 Tight attachments
4.5.2.1 Opa proteins
4.5.2.1.1 OpaHS
4.5.2.1.1.1 Binds heparin sulphate
4.5.2.1.2 OpaCEA
4.5.2.1.2.1 Binds CEACAM
4.5.2.1.2.1.1 Uptake
4.5.3 Change surface proteins
4.5.3.1 Recombination
4.5.3.1.1 Transformation
4.5.3.1.2 Gene exchange
4.5.3.2 Antigenic variation
4.5.3.2.1 Abberant recombination
4.5.3.2.1.1 L-pilin
4.5.3.2.1.1.1 PilS and PilE unequal exchange
4.5.3.2.1.1.2 Stuck in periplasm
4.5.3.2.1.1.3 Evades immune system recognition
4.5.3.2.1.2 S-pilin
4.5.3.2.1.2.1 Secreted soluble pilin molecular decoy
4.5.3.2.2 PilE and PilS exchange
4.5.3.2.2.1 E for expressed
4.5.3.2.2.2 Genetic recombination between homologous segments
4.5.3.3 Phase variation
4.5.3.3.1 Homopolymeric repeats
4.5.3.3.2 Tetranucleotide repeats
4.5.3.3.3 PilC
4.5.3.3.3.1 11-12G = off
4.5.3.3.3.2 <11->12 = on
4.5.3.3.4 CTTCT repeats
4.5.3.3.4.1 3,6,9,12 = on
4.5.3.3.4.2 Opa proteins
4.5.3.4 Sialylated lipopolysaccharide
4.5.3.4.1 Resistant to complement and antibodies
4.5.3.4.2 Mimics host cell surface

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