Quiz
PHSI3011 09-1 Auto-, Para-, Endocrine Functions of Bone
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1Autocrine vs paracrine vs endocrine signalling:
Autocrine = Acts on [blank_start]__________[blank_end];
Endocrine = Acts on [blank_start]__________[blank_end];
Paracrine = Acts on[blank_start]__________[blank_end];- AItself
- BDistant tissue
- CNearby tissue
- DExternal organisms
2Fill in the gaps
- ARANKL
- BRANK
- COPG
- DCSF-1
- ECalcitonin
- FPTH
3What does OPG do to RANKL?
- AFuck all
- BInhibits ligand-binding
- CFacilitates ligand-binding
4What effect does Calcitonin have on Osteoblasts?
- AInhibits Osteoblast activity
- BFuck all
- CEnsures their precursor's survival
5What effect does Calcitonin have on Osteoclasts?
- AInhibits Osteoclast activity
- BFuck all
- CEnsures their precursor's survival
6What effect does CSF1 have on Osteoblasts?
- AInhibits Osteoblast activity
- BFuck all
- CEnsures precursor's survival
7What effect does CSF1 have on Osteoclasts?
- AInhibits Osteoclast activity
- BFuck all
- CEnsures precursor's survival
8OCN is a hormone involved in the regulation of glucose metabolism, which improves the sensitivity of target organs to insulin, thus improving glucose handling by the body. …and MAYBE stimulates insulin production/secretion. Still, OCN = ??
- AOsteoCalciN
- BOsteoCalcitoniN
9OCN is the most abundant [blank_start]__________[blank_end] in bone.
- ANon-collagenous protein
- BMineral
- CCollagenous protein
- DNeurotransmitter
- EOsteokine
10ADHR = ??
- AAutosomal Dominant Hypophosphataemic Rickets
- BAdrenal Dominant Hypophosphataemic Rickets
- CAutosomal Dominant Hyperphosphataemic Rickets
- DAdrenal Dominant Hyperphosphataemic Rickets
11OOM = ??
- AOncogenic OsteoMalacia
- BOsteogenic OncoMalacia
12ADHR and OOM are examples of what?
- APhosphate-wasting disorders
- BCalcium-wasting disorders
- CVitamin-D-wasting disorders
- DVitamin-K-wasting disorders
13Mis-sense mutations in [blank_start]__________[blank_end] in ADHR patients at a furin consensus cleavage site results in a resistance to proteolysis.
- AFGF23
- BInterleukin 6
- CInterleukin 15
- DFGF6
14FGF23 regulates [blank_start]__________[blank_end] concentrations in plasma. It’s secreted by osteocytes in response to low [above] or [blank_start]__________[blank_end] Vitamin D.
- APhosphate
- BOPG
- COCN
- DCalcium
- EVitamin D
- FHigh
- GLow
15FGF23 acts on the kidneys, where it [blank_start]__________[blank_end] the expression of NPT2 (a Na-PO4 co-transporter in the proximal tubule). This leads to [blank_start]__________[blank_end] PO4 reabsorption (which results in [blank_start]__________[blank_end] excretion).
- ADecreases
- BIncreases
- CIncreased
- DDecreased
- EIncreased
- FDecreased
Informationen
- Beschreibung
- PHSI3011 09-1 Auto-, Para-, Endocrine Functions of Bone
- Autor
- Gelöschter Nutzer
- Sprache
- English
- Aufrufe
- 17
- Verlauf
- Erstellt am 10 Nov 2017 · aktualisiert am 10 Nov 2017
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