440326
Beschreibung
Quiz von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312
vor mehr als 10 Jahre
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Frage 1
Frage
5% of the human genome is genes that add a phosphate to something using ATP (Kinases)
Antworten
- True
- False
Frage 2
Frage
Which of the following residues can be phosphorylated by kinases?
Antworten
-
Serine
-
Threonine
-
Tyrosine
-
Valine
-
Argenine
-
Glutamic Acid
Frage 3
Frage
How many different kinases are there (roughly)?
Antworten
-
510
-
520
-
530
Frage 4
Frage
In kinases, DFG & RC motifs are highly conserved
Antworten
- True
- False
Frage 5
Frage
Which domains are commonly found in kinase interacting proteins?
Antworten
-
SH1
-
SH2
-
SH3
Frage 6
Frage
SH3 proteins mediate the assembly of proteins structures by binding to proline rich peptides in them
Antworten
- True
- False
Frage 7
Frage
SH domains modulate protein interactions by recognizing and binding to specific proteins by identifying specific peptide sequences
Antworten
- True
- False
Frage 8
Frage
What is the role of PH domains?
Antworten
-
Binding the protein to the ER membrane
-
Binding the protein to the cell membrane
-
Binding the protein to nuclear membrane
Frage 9
Frage
Membranes form what?
Antworten
-
Compartments & permeability barriers
-
Compartments & osmotic barriers
Frage 10
Frage
What mediate membrane functions?
Antworten
-
Proteins
-
Glycolipids
-
Phospholipid concentration
Frage 11
Frage
Mitochondiral membranes contail the most proteins, plasma membranes contain the least (Out of Mitochondrial, Plasma and Myelin membranes)
Antworten
- True
- False
Frage 12
Frage
Most integral membrane proteins span the membrane
Antworten
- True
- False
Frage 13
Frage
Integral proteins interact extensively with what?
Antworten
-
The hydrocarbon chains of lipids
-
The phosphate groups of phospholipids
-
The hydrocarbon tails of phospholipids
Frage 14
Frage
Peripheral proteins are bound to the membrane via the head groups of phospholipids
Antworten
- True
- False
Frage 15
Frage
How do we tell how strongly a membrane protein is associated?
Antworten
-
Try and disassociate it using detergent
-
Try and disassociate it using water
Frage 16
Frage
Baterial Rhodopsin uses heat to pump protons out of the membrane
Antworten
- True
- False
Frage 17
Frage
How is the hydrophobic core formed in baterorhodopsin?
Antworten
-
7 alpha helices
-
7 beta sheets
-
3 alpha helices, 4 beta sheets
Frage 18
Frage
In the case of the highly conserved 'Membrane Spanning Alpha Helix Structure', what must be on the outside?
Antworten
-
Phospholipids
-
Non-polar aa
-
Polar aa
Frage 19
Frage
The membrane spanning alpha helix structure acts as what?
Antworten
-
A scaffold for the active site
-
The active site
-
The channel for the active site to move through
Frage 20
Frage
Transmembrane helices can be predicted by a long string (or more) of hydrophobic amino acids in their aa sequence
Antworten
- True
- False
Frage 21
Frage
What is used to estimate the free energy change of a residue on transfer of a residue to water (i.e. how much energy does it take to disassociate the aa from the protein)?
Antworten
-
A polarity scale
-
An amino scale
-
A pH scale
Frage 22
Frage
An amino acid with high energy lies buried in a hydrophobic region i.e. the membrane
Antworten
- True
- False
Frage 23
Frage
How large is the hydrocarbon core of the membrane?
Antworten
-
30A
-
32A
-
34A
Frage 24
Frage
What is the name of the 20aa section of an integral protein that spans the membrane?
Antworten
-
Pocket
-
Window
-
Scaffold
Frage 25
Frage
How is a Hydropathy plot formed?
Antworten
-
The free energy change for each 20 aa segement plotted against the first aa in each segment
-
The free energy change for each 20 aa segement plotted against the last aa in each segment
-
The free energy change for each 30 aa segement plotted against the first aa in each segment
Frage 26
Frage
What is the point of a hydropathy plot?
Antworten
-
To find which aa are in hydrophobic areas
-
To find the window of integral proteins
-
To find the window of peripheral proteins
Frage 27
Frage
The criterion level for a hydropathy plot is +68
Antworten
- True
- False
Frage 28
Frage
What is Porin an example of?
Antworten
-
Membrane spanning alpha helices
-
Membrane spanning beta sheets
-
Membrane spanning helix/beta sheet structure
Frage 29
Frage
What tends to be the features of membrane spanning beta sheet residues?
Antworten
-
Hydrophobic
-
Hydrophillic
-
Alternating hydrophobic and hydrophilic
Frage 30
Frage
The polarity of the internal aa in a membrane spanning beta sheet depends on the size
Antworten
- True
- False
Frage 31
Frage
Each sheet in the m.s beta sheet arrangement is hydrogen bonded to its neighbor in a parallel manner
Antworten
- True
- False
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