Changing the way you learn

Question	Answer
Prostoglandin Synthase	Converts Arachidonate to Prostoglandin H2
Role of Prostoglandin	Causes inflammation and modulates gastric acid levels
No of enzyme centres in Prostoglandin synthase	2
Cyclooxygenase	Arachidonic Acid + O2 --> Prostoglandin G2
Peroxidase	Prostoglandin G2 --> H20 + Prostoglandin H2
Monotopic protein	Attached to the membrane from one side
Attachment of Prostoglandin synthase	Hydrophobic alpha helices
Integral/Peripheral	Peripheral, but binds strongly enough to be classed as integral
Can be detached by...	Detergent
Location of PS	Inner membrane- as requires substrate of membrane lipid hydrolysis
Substrate of P.S	Hydrophobic
Travel of Substrate	Moves through hydrophobic channel in membrane to active site devoid of water
Binding of aspirin/ibruprofin	Serine 540
Enzyme complexes require...	A high degree of subunit communication
Why have M.E.C's?	Allow specialized function
Charge	Can prevent M.E.C's forming in the wrong conditions
Reason for Complex- Product	Product of one enzyme is so reactive/expensive it's better to pass it directly along a complex
Reason for Complex- Speed	Enzymes are brought closer together and so reactants move between active sites faster
Reason for Complex- Substrate cycling	Allows cycle to happen so heat can be released
Positive Collisional Interaction	Two molecules collide and have enough energy to react
Negative Collisional Interaction	Two molecules collide/don't react due to shape/charge/size issues

Prostaglandin Synthase & Multi-Enzyme Complexes

	Created by gina_evans0312 almost 12 years ago