Prostaglandin Synthase & Multi-Enzyme Complexes

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Flashcards by gina_evans0312, updated more than 1 year ago
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Created by gina_evans0312 almost 7 years ago
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Structural Basis for Biological Function (Membrane Proteins) Flashcards on Prostaglandin Synthase & Multi-Enzyme Complexes, created by gina_evans0312 on 12/14/2013.

Resource summary

Question Answer
Prostoglandin Synthase Converts Arachidonate to Prostoglandin H2
Role of Prostoglandin Causes inflammation and modulates gastric acid levels
No of enzyme centres in Prostoglandin synthase 2
Cyclooxygenase Arachidonic Acid + O2 --> Prostoglandin G2
Peroxidase Prostoglandin G2 --> H20 + Prostoglandin H2
Monotopic protein Attached to the membrane from one side
Attachment of Prostoglandin synthase Hydrophobic alpha helices
Integral/Peripheral Peripheral, but binds strongly enough to be classed as integral
Can be detached by... Detergent
Location of PS Inner membrane- as requires substrate of membrane lipid hydrolysis
Substrate of P.S Hydrophobic
Travel of Substrate Moves through hydrophobic channel in membrane to active site devoid of water
Binding of aspirin/ibruprofin Serine 540
Enzyme complexes require... A high degree of subunit communication
Why have M.E.C's? Allow specialized function
Charge Can prevent M.E.C's forming in the wrong conditions
Reason for Complex- Product Product of one enzyme is so reactive/expensive it's better to pass it directly along a complex
Reason for Complex- Speed Enzymes are brought closer together and so reactants move between active sites faster
Reason for Complex- Substrate cycling Allows cycle to happen so heat can be released
Positive Collisional Interaction Two molecules collide and have enough energy to react
Negative Collisional Interaction Two molecules collide/don't react due to shape/charge/size issues
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