EBV Latency & Burkitts Lymphoma

Frage	Antworten
Stages of Latency	III, II, I, 0
EBN A1, 2, 3A, 3B, 3C	Family of transcriptional regulators that influence viral gene transcription
LMP1	Viral mimic of CD40 on B cell surface- important for B cell transformation
LMP2	Effects cell signalling & is believed to inhibit the lytic cycle
Proteins expressed in Latency 0	EBER's and miRNAs (no viral genes)
Non Antigenic EBN	EBNA1
Burkitts Lymphoma- Location	Around the malaria belt
Burkitts Lymphoma- Age	Children mostly
Reason for Location	Immunomodulation of the parasite
EBV Conversion	B cells into lymphoblastic cell lines
Key Feature of Burkitt's Lymphoma Cases	Chromosomal rearrangement between one of the heavy/light chain enforcers/promoters & the c-myc oncogene
Deregulate Gene in Burkitt's Lymphoma	c-Myc
Accompanying Mutation	p53 mutation
Source of Burkitt's Lymphoma	Cell surface phenotype suggests Germinal Centre B cells, but limited protein production suggests memory B cells

Zusammenfassung der Ressource

	Erstellt von gina_evans0312 vor etwa 10 Jahre