Flashcards
EBV Infection
Cards in this deck (20)
- 1Age of hostDetermines the effect of primary infection
- 2EBV Carriers at Risk of CancerImmunocompromised & genetically unlucky
- 3Virus IntegrationDoesn't happen- remains an extrachromosomal episome
- 4Genome Size & TypeLarge DNA virus
- 5Genome StabilityHigh- rarely mutates
- 6LatencyEnters this phase in some hosts- the form that causes cancers
- 7Avoiding Immune Surveillance- Avoid Cytotoxic T-CellBlocking antigen processing/presenting by phagocytes
- 8Avoiding Immune Surveillance- LatencySuppression of viral gene expression that makes immune detection impossible
- 9Avoiding Immune Surveillance- Response ModificationEBV can modify the immune response to its detection, causing the release of inflammatory cytokines
- 10Source of InfectionUsually through saliva
- 11Site of InfectionMost commonly B cells
- 12CD21Together with CD19, it forms the B cell receptor- EBV binds to it to enter the cell
- 13GP350Used by EBV to bind to CD21, which allows it to enter the cell by endocytosis
- 14Viral Replication CycleLytic
- 15Characteristic Of Lytic ReplicationIgG's against viral capsid proteins
- 16Exit From CellEndocytosis, so cell isn't killed
- 17Viral DNA PolymeraseResponsible for copying the genome in the lytic cycle
- 18Products of Latency StageDoesn't result in EB virons, allowing it to avoid the immune system
- 19Length of Infection Before Latency is Activated3 to 6 weeks
- 20Host DNA PolymeraseResponsible for copying the genome in the latent phase
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- Virology (Epstein Barr Virus) Flashcards on EBV Infection, created by gina_evans0312 on 10/02/2014.
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- gina_evans0312
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