762353
Beschreibung
Karteikarten von gina_evans0312, aktualisiert more than 1 year ago
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Erstellt von gina_evans0312
vor etwa 10 Jahre
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| Frage | Antworten |
| Penicillin | 1st drug used, now resistance in 90% of strains |
| Source of Penicillin Resistance | Beta-Lactamases are produced that break down the B-lactam ring |
| Methicillin/Cloxacillin | Now used on resistant strains (except MRSA, which is resistant) |
| Source of Methacillin/Cloxacillin Resistance | Alteration of Penicillin Binding Protein |
| MRSA | Methacillin Resistant Staph. aureus (very nasty) |
| SscMec | Mobile genetic element present in MRSA that confers multiple antibiotic resistances |
| SscMec Variations | Many, each conferring different combo of resistances |
| SscMec (MecA) | MecA codes for altered Penicillin Binding Protein |
| SscMec (Insertion Elements) | Part of SsCMec that trap and cluster resistance elements, including macrolytes and others |
| SscMecII | Hospital MRSA |
| SscMecIV | Community MRSA (much smaller element) |
| Treating MRSA- Vancomycin | Targets and removes d-ala to prevent peptide links & blocks transpeptidase |
| Treating MRSA- Vancomycin Issues | Same as Gentamycin |
| Treating MRSA- Daptomycin | Acts on K+ channels, causing leakage and limiting DNA, RNA & protein function |
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