Cyotoxic T-Lymph

Frage	Antworten
Role	To clear bacterial/viral/ parasitic infections
Activation- ICAM	Found on the host cell, part of the binding that allows the CTL to check the MHCI
Activation- LFA-1	Receptor on the host cell that binds to ICAM and allows the CTL to check the MHCI
Activation- MHCI	Contains presented antigens- foreign antigens or a lack of MCH trigger cytotoxicity
Activation- Contact Dependent Ca2+ Dependent Cytotoxicity	Where granule release is mediated by an increase intracytoplasmic Ca2+
Activation- Contact Dependent Ca2+ Dependent Cytotoxicity (Ca2+)	Needed to move granules to side of cell where interaction takes place
Activation- Contact Dependent Ca2+ Dependent Cytotoxicity (Perforin)	Polymerises on target cell and creates pores (requires Ca2+)
Activation- Contact Dependent Ca2+ Dependent Cytotoxicity (Granzymes)	Enter through pores and induce apoptsosis
Activation- Contact Dependent Ca2+ Dependent Cytotoxicity (Caspases)	Granzymes trigger a caspase cascade causing apoptosis
Activation- Fas-Fas Ligand Interaction (Fas Ligand)	Activated CTL induces Fas receptor on target cell
Activation- Fas-Fas Ligand Interaction (Fas Receptor)	CTL possesses Fas ligand to activate the caspase aptotic response
CTL Protection	Surface cathespin B protects cell from destruction by its own released granzymes

Zusammenfassung der Ressource

	Erstellt von gina_evans0312 vor etwa 10 Jahre