Flashcards
Cell Signalling I
Cards in this deck (23)
- 1Intercellular communcationPara/auto/endo/juxtacrine
- 2ParacrineSignal affects close prox. cells
Lim travel - 3AutocrineSender+target same cell
type of paracrine - 4EndocrineUsually acts on distant cells
can affect nearby
hormones - 5JuxtacrineSignalling cell in direct contact / target cell
Gap junction connexons OR
signalling protein on cell surface one cell physically interacts w/ receptor of other - 6Cell influence response1) Reg its R #
2) Synth. dif. isoforms of R
3) Most ligands are hydrophilic, can't pass through LBL, don't cause a response. - 7Cell signalling for cell surface R's (9)1. Pack+synth of sig mol. into IC vesicles.
2. Release into EC space by exo
3. Transport to R
4. Binding of sig to spec. cell surf R, induces conf. Δ+ activation.
5. +R then + dwnstream sig transduct. pro/2' mess.
6. Leads to + of E protein(s)
7a. Short-term Δ
7b. Long-term Δ (gene expression)
8. Term of response by - FDBCK from IC sig mol.
9. Removal of EC signal - 8Modification of proteins for signal transductionProtein cov. mod by +Pi
+Pi usually induces confo Δ
+Pi added from ATP by PK
-Pi by phosphatase - 9How is this tightly regulated?Opportunity to amplify/regulate and control pathway at every level
- 10Termination of SignalEliminate EC ligand
Deactivate signal transduction proteins
Remove +R from PCM via Endocytosis - 11Eliminate EC ligandenzymatic degradation
- 12Deactivate signal transduction proteins-Pi by phosphatases
- 13Remove +R from PCM via EndocytosisR+L internalised
Either:
Seperated, R recycled, L destroyed
OR:
Both destroyed - 14Natural endogenous kinases (3)Hormones
Cytokines
Growth Factor - 15Hormone Detection via cell surf R (3)Small H2O sol. mols
H2O sol. peptide homones
Lipophilic mols - 16Detection via IC R'sLipophilic mols that penetrate the PCM
e.g. steroids - 17Cytokines (3)Peptides of varying sizes
Act over short distances
Co-ordinate immune system - 183 Examplese.g. Interleukins/interferons/tumour necrosis factor
- 19Growth factors (3)Peptides of varying sizes
Para/autocrine signalling
Regulates growth+differentiation - 20AgonistBind and + R, inducing signal + bioresponse
- 21AntagonistsBinds R, doesn't induce signalling
- 22Degrees of agonist actionFull/partial leads to full/partial activation
- 23Factors of drug actionAffinity = ability of drug to bind to specific R
Intrinsic action = inherent ability to induce bio signalling
1= how well natural ligand works, the benchmark
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- User has deleted their subject information Flashcards on Cell Signalling I, created by Deleted user on 31/03/2018.
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- Created by J yadonknow · Mar 31, 2018
- Copied by J yadonknow · Mar 31, 2018
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