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Flashcards

Adrenergic Agonist

Courtney P Cardiology Med Chem English 33 cards

Adrenergic Agonist

Cards in this deck (33)

  1. 1—Epinephrine
    Phenylethanolamine (aka catecholamine)
    a & B
    R isomer    Epinephrine Phenylethanolamine (aka catecholamine) a & B R isomer
  2. 2—Norepinephrine
    Phenylethanolamine (aka catecholamine)
    a & B    Norepinephrine Phenylethanolamine (aka catecholamine) a & B
  3. 3—Isoproterenol
    Phenylethanolamine (aka catecholamine)
    General B    Isoproterenol Phenylethanolamine (aka catecholamine) General B
  4. 4—Isoetharine
    Phenylethanolamine (aka catecholamine)
    Selective, B2
    Slower MAO metabolism    Isoetharine Phenylethanolamine (aka catecholamine) Selective, B2 Slower MAO metabolism
  5. 5—Metaproterenol
    Phenylethanolamine (aka catecholamine)
    Selective, B2
    Poor COMT metabolism    Metaproterenol Phenylethanolamine (aka catecholamine) Selective, B2 Poor COMT metabolism
  6. 6—Phenylephrine
    Phenylethanolamine (aka catecholamine)
    Selective a1 (-OH)    Phenylephrine Phenylethanolamine (aka catecholamine) Selective a1 (-OH)
  7. 7—Ephedrine
    Phenylethanolamine (aka catecholamine)
    Direct
    1R, 2S    Ephedrine Phenylethanolamine (aka catecholamine) Direct 1R, 2S
  8. 8—Pseudoephedrine
    Phenylethanolamine (aka catecholamine)
    Indirect (unsubstituted ring)
    1R, 2R    Pseudoephedrine Phenylethanolamine (aka catecholamine) Indirect (unsubstituted ring) 1R, 2R
  9. 9—Tetrahydrozoline
    2-Arylimidazoline
    a1 - agonist, selective    Tetrahydrozoline 2-Arylimidazoline a1 - agonist, selective
  10. 10—Oxymetazoline (afrin)
    2-Arylimidazoline
    a1 - agonist    Oxymetazoline (afrin) 2-Arylimidazoline a1 - agonist
  11. 11—Naphazoline
    2-Arylimidazoline
    a1 - agonist    Naphazoline 2-Arylimidazoline a1 - agonist
  12. 12—Clonidine
    2-Arylimidazoline
    Selective a2- agonist
    CNS activity, antihypertensive    Clonidine 2-Arylimidazoline Selective a2- agonist CNS activity, antihypertensive
  13. 13—Apraclonidine
    2-Arylimidazoline
    Selective a2-agonist    Apraclonidine 2-Arylimidazoline Selective a2-agonist
  14. 14—Brimonidine
    2-Arylimidazoline
    Selective a2- agonist
    Glaucoma    Brimonidine 2-Arylimidazoline Selective a2- agonist Glaucoma
  15. 15—Tizanidine
    2-Arylimidazoline
    Selective a2- agonist
    CNS activity, muscle relaxant    Tizanidine 2-Arylimidazoline Selective a2- agonist CNS activity, muscle relaxant
  16. 16—Guanfacine
    Ring-opened Aryl-imidazole Analogs
    Selective a2- agonist    Guanfacine Ring-opened Aryl-imidazole Analogs Selective a2- agonist
  17. 17—Guanabenz
    Ring-opened Aryl-imidazole Analogs
    Selective a2- agonist    Guanabenz Ring-opened Aryl-imidazole Analogs Selective a2- agonist
  18. 18—Methyldopa
    Amino acid - Pro-drug
    Selective a2- agonist
    CNS activity, Tx HTN    Methyldopa Amino acid - Pro-drug Selective a2- agonist CNS activity, Tx HTN
  19. 19—Albuterol
    Short-acting B2 agonist
    R isomer is active
    Resistant to MAO and COMT    Albuterol Short-acting B2 agonist R isomer is active Resistant to MAO and COMT
  20. 20—Terbutaline
    Short-acting B2 agonist
    Resistant to MAO and COMT    Terbutaline Short-acting B2 agonist Resistant to MAO and COMT
  21. 21—Salmeterol
    Long-acting B2 agonist
    Albuterol + lipophilic tail
    Bronchodilatory effect    Salmeterol Long-acting B2 agonist Albuterol + lipophilic tail Bronchodilatory effect
  22. 22—Formoterol
    Long-acting B2 agonist    Formoterol Long-acting B2 agonist
  23. 23—Indacterol
    Ultra long-acting B2 agonist
    DOA (24+ hours)
    Lactam ring    Indacterol Ultra long-acting B2 agonist DOA (24+ hours) Lactam ring
  24. 24—Olodaterol
    Ultra long-acting B2 agonist
    DOA (24+ hours)
    Lactam ring    Olodaterol Ultra long-acting B2 agonist DOA (24+ hours) Lactam ring
  25. 25—Vilanterol
    Ultra long-acting B2 agonist
    DOA (24+ hours)
    Lactam ring    Vilanterol Ultra long-acting B2 agonist DOA (24+ hours) Lactam ring
  26. 26—Dopamine
    Selective B1 agonist and DA receptors
    Shock, MI, trauma, CHF
    Rapidly metabolized by COMT an MAO    Dopamine Selective B1 agonist and DA receptors Shock, MI, trauma, CHF Rapidly metabolized by COMT an MAO
  27. 27—Dobutamine
    Selective B1 agonist
    Cardiac stimulant    Dobutamine Selective B1 agonist Cardiac stimulant
  28. 28—Mirabegron
    Selective B3 agonist (bladder)
    Tx: overactive bladder (and weight loss)
    SE: hypertension (a1 agonist)
    Slow metabolism    Mirabegron Selective B3 agonist (bladder) Tx: overactive bladder (and weight loss) SE: hypertension (a1 agonist) Slow metabolism
  29. 29—Amphetamine
    Phenethylamine
    Indirect, CNS activity    Amphetamine Phenethylamine Indirect, CNS activity
  30. 30—Methamphetamine
    Phenethylamine
    Indirect, CNS activity
    Methyl group has most activity    Methamphetamine Phenethylamine Indirect, CNS activity Methyl group has most activity
  31. 31—Methylphenidate
    Phenethylamine/amphetamine derivative
    NE/DA reuptake inhibitor - Indirect    Methylphenidate Phenethylamine/amphetamine derivative NE/DA reuptake inhibitor - Indirect
  32. 32—Dexmethylphenidate
    Phenethylamine/amphetamine derivative
    Indirect    Dexmethylphenidate Phenethylamine/amphetamine derivative Indirect
  33. 33—Lisdexamphetamine
    Pro-drug of dextroamphetamine - slow metabolism - increased DOA
    Indirect - catechol uptake inhibitor    Lisdexamphetamine Pro-drug of dextroamphetamine - slow metabolism - increased DOA Indirect - catechol uptake inhibitor

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Cardiology Med Chem Flashcards on Adrenergic Agonist, created by Courtney P on 28/01/2019.
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Courtney P
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