Flashcards

TLRs

Eleanor Smith Immunology and Microbiology FHS Part I English 11 cards

Cards in this deck (11)

1TLR1:TLR2 heterodimerLipopeptides
GPI
2TLR2:TLR6 heterodimerLipoteichoic acid
Zymosan
3TLR3double stranded viral RNA
found on NK cells
4TLR4 homodimerLipopolysaccharide
5TLR5Flagellin
6TLR7Single stranded viral RNA
7TLR8Single stranded viral RNA
found on NK cells
8TLR9Unmethylated CpG-rich DNA
9TLR10 homodimer and heterodimer with TLR1 and 2Unknown
10What are TLRs?Non-opsonic, non-phagocytic receptors that sense pathogens and trigger inflammatory signalling pathways leading to inflammatory cytokine production
11LPS recognition and signallingA complex of TLR4, MD2, CD14 and LPS is assembled at the macrophage surface
MyD88 binds TLR4 and activates IRAK4 to phosphorylate TRAF6, which leads to phosphorylation of IKK
IKK phosphorylates IkB, leading to its degradation and release of NFkB, which enters the nucleus
NFkB activates transcription of genes of inflammatory cytokines, which are synthesised in cytoplasm and secreted via ER

Description: FHS Part I Immunology and Microbiology Flashcards on TLRs, created by Eleanor Smith on 17/09/2020.
Created by: Eleanor Smith
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