Flashcards
AINEs on PGs
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- 1Cyclooxygenase (COX) converts arachidonic acid to prostaglandin (PG) H2 . COX exists in at least two different isoforms. Prostaglandin endoperoxide H synthases (cyclooxygenases, COX)2 , which is further metabolized to various prostaglandins, prostacyclin and thromboxane A2 COX-1 is constitutively expressed, whereas COX-2 is induced by proinflammatory stimuli. Prostaglandin E2 is a major metabolite of COX activationHorton. Analytical Biochemistry 271, 18–28 (1999)
- 2Constitutive cyclooxygenase (COX-1; prostaglandin-endoperoxide synthase, EC 1.14.99.1) is present in cells under physiological conditions, whereas COX-2 is induced by some cytokines, mitogens, and endotoxin presumably in pathological conditions, such as inflammation.Mitchell et al. Proc. Natl. Acad. Sci. USA Vol. 90, pp. 11693-11697, 1994
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- 16 abril MINECO 2016 (MyAINEs) Flashcards on AINEs on PGs, created by Joseba Pineda on 03/04/2016.
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- Joseba Pineda
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