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Secondary (invivo) screening
Cards in this deck (10)
- 1In-vivo preparations1. Anesthetized cat blood pressure.
2. Cat nictitating membrane - 2Anesthetized cat blood pressure preparationAnimals are cannulated at 3 sites:
1. Tracheal cannulation.
2. Femoral vein cannulation.
3. Femoral artery cannulation - 31. Tracheal cannulationPolyethylene cannula is introduced into the trachea, cannula is connected to respirometer (artificial ventilator) to overcome respiratory pralysis produced by skeletal muscles relaxants.
- 42. Femoral vein cannulationThrough a small cut in the vein connected to a syringe for IV adminstration of drugs
- 53. Femoral artery cannulationThe femoral artery is connected to a blood pressure transducer for blood pressure measurement which converts blood pressure to electronic signals which are recorded on a multi-channel system
- 6Tetrad system1. Electrical vagal stimulation.
2. IV administration of acetylcholine.
3. Bilateral Carotid Occlusion (OCB).
4. IV administration of epinephrine or norepinephrine. - 7Vagus nerveThe parasympathetic nerve supplying the heart & GIT.
- 8Vagus nerve originIt originates from 2 nuclei in the meddula oblongata
1. Dorsal motor nucleus of vagus (DMV)
2. Nucleus ambiguous (NA) - 91. Electrical vagal stimulation1. The neck area is opened and one of the two vagi is dissected.
2. Vagus nerve is stimulated electrically (preganglionic stimulation) - 10Effect of electrical vagal stimulation1. Release of endogenous Acetylcholine which affects \[M_2\] receptor in heart.
2. Bradycardia → decreased cardiac output → hypotension.
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- The invivo preparations and the tests carried on them
- Created by
- Ayman Barghout
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