Flashcards
Lymphocyte Development
Cards in this deck (8)
- 1name and explain the 4 stages of producing an antigen receptor1. gene rearrangment - codes for receptor, 2. lineage committment - chooses B or T cells, 3. Education gets rid of autoreactive or non-resposive cells 4. functional maturation - achieve an appropriate affinity for MHC
- 2whats happens in equie SCIDno VDJ recombination, so no T/B cells produced
- 3what is central tolerance?if thymocyte reacts strongly to self-MHC then it will be deleted
prevents autoimmunity - 4what is self tolerance?if T cell is unable to recognise a self peptide bound to a self-MHC then it will be deleted
(has to recognise when its a self antigen and not attack so it knows when to attack a foreign antigen) - 5whta are lymphocytes derived from?pluripotent haematopoetic stem cells
- 6where do T and B cells mature?B - bone marrow, T- thymus
- 7what do B cells recognise?native proteins
- 8what do T cells recognise?degraded proteins bound to MHC
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- (LYM) Flashcards on Lymphocyte Development, created by becki_fernandes on 29/04/2013.
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