Flashcards
Aspirin
Cards in this deck (4)
- 1Give indications for aspirin.• ACS & acute ischaemic stroke - to rapidly inhibit platelet aggregation & prevent or limit arterial thrombosis
• Long term secondary prevention of thrombotic arterial events with CVS, cerebrovascular, & peripheral arterial DS
• AF where warfarin & NOAC's are CI
• Mild-to-moderate P & fever - NSAID's may be preferable - 2MOA of aspirin.Thrombotic events occur when platelet-rich thrombus forms in atheromatous arteries & occludes the circulation. Aspirin irreversibly inhibits cyclooxygenase (COX) to reduce production of the pro-aggregatory factor thromboxane from arachidonic acid, reducing platelet aggregation & the risk of arterial occlusion. The antiplatelet effect of aspirin occurs at low doses and lasts for the lifetime of a platelet (which does not have a nucleus to allow synthesis of new COX) and thus only wears off as new platelets are made.
- 3SE's of aspirin.• GI irritation
• GI ulceration & haemorrhage
• Bronchospasm
• Tinnitus - in high doses - 4CI's, cautions, & important interactions of aspirin.CI's:
• <16 YO
• Aspirin hypersensitivity
• 3rd trimester of pregnancy
Cautions:
• Peptic ulcer (eg prescribe gastroprotection)
• Gout
Important interactions:
Aspirin acts synergistically with other antiplatelet agents, which although therapeutically beneficial can lead to increased risk of bleeding. Thus, although it may be given with antiplatelet drugs (e.g. clopidogrel, dipyridamole) & anticoagulants (e.g. heparin, warfarin) in some situations (e.g. acute coronary syndrome), caution is required.
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- Top 100 drugs.
- Created by
- Andrew Street · Oct 2016
- Updated
- Oct 22, 2016
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