Flashcards
Cell Signalling lecture
Cards in this deck (7)
- 1What are the key components of a signalling pathway?Ligand, Receptor, Transducer & Effector
- 2Name the 5 key developmental signalling pathwaysHedgehog Pathway
Notch Pathway
Wnt Pathway
TGFB Pathway
FGF Pathway - 3Name the ligand, receptor, transducer & effector of the hedgehog pathwayLigand: Sonic hedgehog (Shh)
receptor: patched
transducer: Smoothered
Effector: Gli (2 & 3) - 4Name the ligand, receptor, transducer & effector of the Notch pathwayligand: Delta
Receptor: Notch
Transducer: NICD
Effector: RBPjK - 5Name the ligand, receptor, transducer & effector of the Wnt Pathwayligand: Wnt
Receptor: frizzled/LRP
transducer: Dishevelled
effector: B-canetin - 6Name the ligand, receptor, transducer & effector of the FGF pathwayligand: FGF
receptor: FGFR
transducer: ERK/AKT
effector: ETS - 7How does cell signalling come about?Endocrine: through bloodstream
Paracrine: neighboring cells
Autocrine: cell releases signal & captures it itself