Flashcards
Hormones II
Cards in this deck (18)
- 1BridgeIsthmus
- 2HistologyFunctional unit: Follicle
Layer of simp cub. epi follicle cells around a colloid-filled lumen - 3Thyroid Hormones areT4 thyroxine, T3 Trriodothyronine
AA iodinated tyrosine hormones - 4What are they bound to and why?Bound to Thyroxine-binding Globulin
Or Albumin
Prevents renal excretion - 5T1/2rT3 - 5 hours
T3 - 1-3 Days
T4 - 5-7 Days - 6TH synthesis (8)1. Thyroglobulin synth + secreted by follicle cells into colloid lumen.
2. I- trapped and A.T. into lumen.
3. I- [O] -> I2 by TPO
4. I2 attached to Tyr in colloid forming DIT/MIT
5. I-tyr linked to form T3/T4
6. Thyroglobulin endocytosed into follicle cells and combined with a lysosome.
7. Lysosomal Ez cleave T3/T4 from TG and hormone diffuses into circulation.
8. Bind to T-B G or Albumin - 7Major Advantage of ThyroidThyroid Gland can store TH in colloid
Release when I2 is scarce - 8What conversion takes place in perinephral tissues?T4->T3
- 9Principle action of THMetabolism - increases mobilisation of glucose/fat/protein.
Calorigenic effect - 'c reg. + adaptation to cold environment.
Growth + Development -synergy w/ GH - 10-FDBCK of THexternal conditions
Hypothalamus
A.P.
TSH
TG
T3/T4 - 11What does TSH stimulate? (3)Every aspect of thyroid functioning e.g:
1. Promote release of TH into blood.
2. Increased activity of Iodine pumps.
3. Iodination of tyrosine to increase production of TH's. - 12Hypothyroid causesUnderactive thyroid
Iodine deficiency - 13Symptoms of hypothyroidismmet rate decreases, weight increases
Low plasma T3/T4
High TSH and TRH - 14Hashimoto's DiseaseAutoimmune
AB attack:
TSH R
TPO
Thyroglobulin
Causes autodestruction of Follicles - 15Treatment for hypothyroidismL-thyroxine
- 16hyperthyroidism (4)Excessive sweating
bulging eyes
^ met. rate and O2 consumption
^HR - 17Graves DiseaseAbnormal AB mimics TSH
+ TSH R, induces T3/T4 release - 18Treatment for hyperthyroidismSurgical removal of thyroid gland
Radiactive Iodine to selectively destroy most active thyroid glands
Drugs that interfere w/ I- -> I2 conversion
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- User has deleted their subject information Flashcards on Hormones II, created by Deleted user on 01/05/2018.
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- Created by J yadonknow · Apr 1, 2018
- Copied by J yadonknow · May 1, 2018
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